{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:48:06Z","timestamp":1762876086390,"version":"3.41.2"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870491"],"award-info":[{"award-number":["31870491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>\u03b2\u2010Carotene (BC), a substitute for vitamin A, is widely used for its benefits. The present study investigates whether in\u2010utero BC administration can alter lipid and glucose homoeostasis in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Pregnant mice are supplemented with BC (1 mg kg<jats:sup>\u22121<\/jats:sup> weight) by oral gavage once every 3 days, for a total of six doses. Increased visceral fat may be caused by up\u2010regulated PPAR\u03b3 (peroxisome proliferator\u2010activated receptor gamma) and RXR\u03b1\/\u03b2 (retinoid X receptors) in liver and adipose tissue, and glucose intolerance is observed in F1 adult females prenatally supplemented with BC, while F1 males do not exhibit these symptoms. In females, increased serum leptin, resistin, and IL\u20106 and reduced adiponectin, caused by visceral obesity, may result in downregulated insulin receptor signaling in muscle and further account for glucose intolerance. Increased pancreatic \u03b2\u2010cell mass might compensate for the downregulated insulin gene (<jats:italic>ins2<\/jats:italic>). Increased glucagon and \u03b1\u2010cell mass, accompanied by upregulated glucagon gene (<jats:italic>gcg<\/jats:italic>), might also be risk factors for the development of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal supplementation with BC disturbs lipid metabolism and induces glucose intolerance in F1 female mice, suggesting that BC supplementation during pregnancy should be used with caution.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900072","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T02:16:29Z","timestamp":1551320189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal Supplementation with \u03b2\u2010Carotene During Pregnancy Disturbs Lipid Metabolism and Glucose Homoeostasis in F1 Female Mice"],"prefix":"10.1002","volume":"63","author":[{"given":"Jiaojiao","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology School of Life Sciences Xiamen University  Xiamen 36110 P. 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