{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:21Z","timestamp":1787236521568,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Cause\u2010effect relationship between vitamin D deficiency and cardiometabolic abnormalities remains undefined. The aim is to investigate the role of vitamin D deficiency in cardiac failure, through possible involvement in myocardial insulin signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Male SD rats (\n                      <jats:italic>n<\/jats:italic>\n                      = 6) are fed a normal diet (Con), vitamin D\u2010deficient diet [Con(\u2010)], or high\u2010fat, high fructose diet (HFHFrD) for 20 weeks. Cardiac hypertrophy and fetal gene program are confirmed in Con(\u2010) group. Cardiac dysfunction is assessed by echocardiography. Elevated renin, TGF\u2010\u03b2 and collagen\u20101\u03b1 mRNAs, p\u2010ERK1\/2, and perivascular fibrosis indicate cardiac remodeling in Con(\u2010) group. Increased serum insulin, triglycerides, and blood pressure, and decreased glucose tolerance and HDL cholesterol are observed in Con(\u2010) rats. Decreased p\u2010Akt\/Akt, GLUT4, SOD2, and catalase, and increased NF\u2010\u03baB, TNF\u2010\u03b1, and IL\u20106 are observed in Con(\u2010) hearts. In H9c2 cells, calcitriol attenuates palmitate\u2010induced insulin resistance. VDR\u2010silenced H9c2 cells show reduced Akt phosphorylation, GLUT4 translocation, and 2\u2010NBDG uptake. Findings in Con(\u2010) and HFHFrD groups are comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency in rats mimic high\u2010fat\u2010, high\u2010fructose\u2010induced metabolic syndrome and cardiac dysfunction. This study demonstrates that vitamin D deficiency is an independent risk factor for heart failure, at least in part, through induction of myocardial insulin resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201900109","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T13:55:36Z","timestamp":1558014936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing Myocardial Insulin Resistance"],"prefix":"10.1002","volume":"63","author":[{"given":"Hina Lateef","family":"Nizami","sequence":"first","affiliation":[{"name":"Drug Discovery Research Center Translational Health Science and Technology Institute  Faridabad 121001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmeshwar","family":"Katare","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Center 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