{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:23:21Z","timestamp":1778887401152,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008749","name":"Zhejiang Academy of Agricultural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p><jats:italic>Angelica keiskei<\/jats:italic> is associated with several health benefits, but little is known about the effect of <jats:italic>A.\u00a0keiskei<\/jats:italic> juice (AKJ), which is rich in polyphenols, coumarins, and other healthful agents, on high\u2010fat diet\u2010induced obesity or its relationship with intestinal microbiota composition changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6 mice are fed either a normal diet (ND group; <jats:italic>n<\/jats:italic> = 8), a high\u2010fat diet (HFD group; <jats:italic>n<\/jats:italic> = 8), or a high\u2010fat diet supplemented with AKJ (AKJ group; <jats:italic>n<\/jats:italic> = 8) for 10 weeks. The results show that AKJ prevents weight gain, lowered fat accumulation, blood glucose, serum lipid levels, hepatic steatosis, and modulates the level of expression of genes involved in lipid metabolism in mice with obesity. AKJ is found to normalize HFD\u2010induced gut dysbiosis. Particularly, AKJ ameliorates HFD\u2010dependent changes in the relative abundance of several taxa back to normal status (e.g., AKJ increased <jats:italic>Bacteroides<\/jats:italic> and decreased <jats:italic>Mollicutes_RF9<\/jats:italic>, <jats:italic>Ruminococcaceae_UCG\u2010014<\/jats:italic>, <jats:italic>Faecalibacterium<\/jats:italic>, and <jats:italic>Lactobacillus<\/jats:italic>). Spearman's correlation analysis reveals that those genera are closely correlated with body weight, fasting serum glucose, and serum lipid levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results show that consumption of phytochemical\u2010rich AKJ may prevent HFD\u2010induced obesity and metabolic disorders via changes in metabolic genes and gut microbiota composition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900248","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:44:47Z","timestamp":1559954687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Daily Supplementation with Fresh <i>Angelica keiskei<\/i> Juice Alleviates High\u2010Fat Diet\u2010Induced Obesity in Mice by Modulating Gut Microbiota Composition"],"prefix":"10.1002","volume":"63","author":[{"given":"Chengcheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou 310021 China"},{"name":"Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province  Hangzhou 310021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou 310021 China"},{"name":"Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province  Hangzhou 310021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Li","sequence":"additional","affiliation":[{"name":"Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou 310021 China"},{"name":"Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province  Hangzhou 310021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Xin","sequence":"additional","affiliation":[{"name":"Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou 310021 China"},{"name":"Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province  Hangzhou 310021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4232-1916","authenticated-orcid":false,"given":"Daqun","family":"Liu","sequence":"additional","affiliation":[{"name":"Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou 310021 China"},{"name":"Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province  Hangzhou 310021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.84.s1.02"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05414"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2016.01.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.165"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407076101"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12738"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2015.3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.11.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307142"},{"key":"e_1_2_7_12_1","author":"Anhe F. 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