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T1D incidence, gut barrier function, and pancreatic\u2010gut immune responses are analyzed. LMP supplementation significantly dampened the onset of T1D in NOD mice. LMP supplementation induces caecal homeostasis, as indicated by the increasing SCFAs production, higher expression of tight junction proteins claudin 1, zonula occludens\u20102 in caecum. Furthermore, LMP\u2010mediated caecal homeostasis impacts gut\u2010pancreatic immunity, as evidenced by increased regulatory T cell population, modulated inflammatory cytokine expression, and suppressed NOD like receptor protein 3 (NLRP3) inflammasome activation in both caecum and pancreas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data demonstrate that LMP limits T1D development by inducing caecal homeostasis to shape pancreatic immune environment, providing a scientific basis for using LMP as a novel functional supplementation to intervene T1D.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900307","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T03:44:32Z","timestamp":1566186272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction"],"prefix":"10.1002","volume":"63","author":[{"given":"Chengfei","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Jiangnan University  Wuxi 214122 P. 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