{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:55:26Z","timestamp":1783529726432,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009037","name":"Science and Technology Research Partnership for Sustainable Development","doi-asserted-by":"publisher","award":["JPMJSA1506"],"award-info":[{"award-number":["JPMJSA1506"]}],"id":[{"id":"10.13039\/501100009037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, herbs, and dried fruits, exhibits anti\u2010inflammatory, antioxidant, and neuroprotective effects. In the present study, the antidepressant\u2010like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Oral administration of FA at a dose of 5\u00a0mg\u00a0kg<jats:sup>\u20131<\/jats:sup> for 7 days significantly reduces immobility of mice compared to vehicle\u2010administered control group. Microarray and real\u2010time PCR analyses reveal that FA upregulates the expression of several genes associated with cell survival and proliferation, energy metabolism, and dopamine synthesis in mice limbic system of brain. Interestingly, it is found that FA, unlike antidepressant drug bupropion, strongly promotes energy metabolism. Additionally, FA increases catecholamine (dopamine and noradrenaline), brain\u2010derived neurotrophic factor, and ATP levels, and decreases glycogen levels in the limbic system of the mice brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The research provides the first evidence that FA enhances energy production, which can be the underlying mechanism of the antidepressant\u2010like effects of FA observed in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900327","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T18:52:46Z","timestamp":1565290366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Antidepressant\u2010Like Effect of Ferulic Acid via Promotion of\u00a0Energy Metabolism Activity"],"prefix":"10.1002","volume":"63","author":[{"given":"Kazunori","family":"Sasaki","sequence":"first","affiliation":[{"name":"Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138572 Japan"},{"name":"Interdisciplinary Research Center for Catalytic Chemistry National Institute of Advanced Industrial Science and Technology (AIST)  AIST Tsukuba Central 5\u20102 Tsukuba Ibaraki 305\u20138565 Japan"},{"name":"Faculty of Pure and Applied Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138571 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Iwata","sequence":"additional","affiliation":[{"name":"School of Integrative and Global Majors (SIGMA) University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138577 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Ferdousi","sequence":"additional","affiliation":[{"name":"Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138572 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Isoda","sequence":"additional","affiliation":[{"name":"Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138572 Japan"},{"name":"Interdisciplinary Research Center for Catalytic Chemistry National Institute of Advanced Industrial Science and Technology (AIST)  AIST Tsukuba Central 5\u20102 Tsukuba Ibaraki 305\u20138565 Japan"},{"name":"Faculty of Life and Environmental Sciences University of Tsukuba  Japan1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20138572 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_7_1_1","volume-title":"Depression and Other Common Mental Disorders. 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