{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:19:13Z","timestamp":1790007553373,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Groupe PiLeJe"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Targeting gut microbiota dysbiosis by prebiotics is effective, though side effects such as abdominal bloating and flatulence may arise following high prebiotic consumption over weeks. The aim is therefore to optimize the current protocol for prebiotic use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>To examine the prebiotic properties of plant extracts, two independent studies are conducted in ob\/ob mice, over two weeks. In the first study, <jats:italic>Porphyra umbilicalis<\/jats:italic> and <jats:italic>Melissa officinalis L<\/jats:italic>. extracts are evaluated; in the second study, a high vs low dose of an <jats:italic>Emblica officinalis<\/jats:italic> Gaertn extract is assessed. These plant extracts affect gut microbiota, caecum metabolome, and induce a significant lower plasma triacylglycerols (TG) following treatment with <jats:italic>P. umbilicalis<\/jats:italic> and significantly higher plasma free fatty acids (FFA) following treatment with the low\u2010dose of <jats:italic>E. officinalis<\/jats:italic> Gaertn. Glucose\u2010 and insulin\u2010tolerance are not affected but white adipose tissue and liver gene expression are modified. In the first study, <jats:italic>IL\u20106<\/jats:italic> hepatic gene expression is significantly (adjusted <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0015) and positively (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.80) correlated with the bacterial order Clostridiales in all mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data show that a two\u2010week treatment with plant extracts affects the dysbiotic gut microbiota and changes both caecum metabolome and markers of lipid metabolism in ob\/ob mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900403","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T15:57:30Z","timestamp":1560787050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Two\u2010Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob\/ob Mice"],"prefix":"10.1002","volume":"63","author":[{"given":"Amandine","family":"Brochot","sequence":"first","affiliation":[{"name":"Groupe PiLeJe  75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Azalbert","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)  Toulouse France"},{"name":"Unit\u00e9 Mixte de Recherche (UMR) 1048 Institut de Maladies M\u00e9taboliques et Cardiovasculaires (I2MC) Universit\u00e9 Paul Sabatier (UPS)  Toulouse 31432 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Landrier","sequence":"additional","affiliation":[{"name":"Centre de recherche CardioVasculaire et Nutrition (C2VN) Aix\u2010Marseille Universit\u00e9, INRA, INSERM  Marseille 13385 France"},{"name":"CriBioM Criblage Biologique Marseille Facult\u00e9 de M\u00e9decine de la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Tourniaire","sequence":"additional","affiliation":[{"name":"Centre de recherche CardioVasculaire et Nutrition (C2VN) Aix\u2010Marseille Universit\u00e9, INRA, INSERM  Marseille 13385 France"},{"name":"CriBioM Criblage Biologique Marseille Facult\u00e9 de M\u00e9decine de la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4644-8532","authenticated-orcid":false,"given":"Matteo","family":"Serino","sequence":"additional","affiliation":[{"name":"IRSD Universit\u00e9 de Toulouse, INSERM, INRA, ENVT, UPS  Toulouse 31024 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0333-6"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.12.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112799857567"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2009.03.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.6.1401"},{"key":"e_1_2_7_6_1","author":"Van Hul M.","year":"2017","journal-title":"Am. 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