{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:23:53Z","timestamp":1790681033391,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The metabolic response to fed\/fasting changing conditions at early age in rats with different predisposition to obesity\u2010related alterations due to maternal conditions during the perinatal period is studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Offspring of dams made obese by a cafeteria diet and moved to a normal\u2010fat diet 1 month before gestation (O\u2010PCaf, with an apparently normal phenotype in adulthood), and offspring of cafeteria diet\u2010fed dams during lactation (O\u2010CAF, with a thin\u2010outside\u2010fat inside phenotype), together with the offspring of control dams (O\u2010C), are studied at early age. Fasting is associated with downregulation of lipogenesis\u2010related genes in liver and rpWAT, and upregulation of genes related to lipolysis and fatty acid uptake in rpWAT in O\u2010C animals. The response to fed\/fasting conditions is impaired in O\u2010CAF, but not in O\u2010PCaf animals. The fasting\u2010induced increase in the expression of <jats:italic>Prkaa1<\/jats:italic> in liver and rpWAT, and the corresponding increase of hepatic AMPK\u03b11 protein levels of O\u2010C animals are attenuated in O\u2010CAF rats, while no alterations are found in O\u2010PCaf animals versus controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal intake of a cafeteria diet during lactation causes early alterations in the offspring, impairing their metabolic flexibility in response to fed\/fasting changing conditions, which may contribute to hindering energy homeostasis maintenance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900504","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T14:49:03Z","timestamp":1565966943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal Overfeeding during Lactation Impairs the Metabolic Response to 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