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Mannose oligosaccharide (MOS) has been reported to be a potential prebiotic. The present study is aimed to determine the effects of MOS on western\u2010diet\u2010induced obesity and to uncover the mediating roles of the gut microbiota and microbial metabolites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Three\u2010month\u2010old male ICR mice are fed with a high\u2010fat and high\u2010fructose diet for 8 weeks. The diet\u2010induced obese mice are then orally administrated with MOS (100 and 200\u00a0mg\u00a0kg<jats:sup>\u20131<\/jats:sup>\u00a0d<jats:sup>\u20131<\/jats:sup>) for 4 weeks. MOS significantly reduces bodyweight gain, insulin resistance, fatty liver, and inflammatory responses in obese mice. MOS also stimulates lipolysis and inhibits lipogenesis in the adipose tissues. Moreover, MOS restructures the gut microbiome by enhancing the abundance of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> in obese mice. The microbial metabolite SCFAs are also increased in the feces and serum. Correlation analysis indicates that the appetite suppression and lipid\u2010lowering effects of MOS are highly correlated with the butyrate levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MOS suppresses the appetite, which results in less lipid deposition. The lower appetite is likely due to an altered gut microbiome and elevated SCFAs production. MOS may be a potential nutraceutical used in body weight management and gut health improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900521","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T20:26:53Z","timestamp":1567715213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western\u2010Diet\u2010Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short\u2010Chain Fatty Acids Production"],"prefix":"10.1002","volume":"63","author":[{"given":"Shikai","family":"Yan","sequence":"first","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ye","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junru","family":"Pan","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Xi'an Yuensun Biological Technology Co. 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