{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:50:29Z","timestamp":1770155429812,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701209"],"award-info":[{"award-number":["81701209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Recent findings indicate that the ketogenic diet (KD) is neuroprotective and electrical stimulation (ES) can improve functional recovery from peripheral nerve injury. However, it is not clear whether KD and ES play a synergistical role in the peripheral nerve recovery following injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A KD consisting of a 3:1 ratio of fat to carbohydrate\u00a0+\u00a0protein is used and is coupled with ES treatment in a rat model of peripheral nerve crush injury. Neuromuscular recovery is evaluated by electromyography, and axonal regeneration and myelination by histological methods. The effects on insulin\u2010like growth factor 1 (IGF\u20101) and IGF\u20101 receptor expression in peripheral nerve tissue, pre\u2010 and post\u2010nerve injury, are also investigated. The combination of KD and ES synergistically increases muscle force in biceps femoris and gluteus maximus and prevents development of hypersensitivity in biceps femoris. It promotes peripheral nerve regeneration by increasing total axons, axon density, and axonal diameter, as well as myelin thickness and axon\/fiber ratio. These effects are due to modulation of the IGF system as the treatment expression of IGF\u20101 and IGF\u20101 receptor in regenerated nerve tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results establish that KD and ES promote peripheral nerve regeneration. Patients recovering from peripheral nerve injury may benefit from this combinational approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900535","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T20:18:26Z","timestamp":1578514706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ketogenic Diet Potentiates Electrical Stimulation\u2013Induced Peripheral Nerve Regeneration after Sciatic Nerve Crush Injury in Rats"],"prefix":"10.1002","volume":"64","author":[{"given":"Ji","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesia The First Hospital of Jilin University  71 XinMin Street Changchun 130021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery The First Hospital of Jilin University  71 XinMin Street Changchun 130021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010qiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia The First Hospital of Jilin University  71 XinMin Street Changchun 130021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery The First Hospital of Jilin University  71 XinMin Street Changchun 130021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-8625","authenticated-orcid":false,"given":"Rui\u2010jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery The First Hospital of Jilin University  71 XinMin Street Changchun 130021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20633"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-28"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152046.11390.45"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216108.57529.b1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.08.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.79"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0050-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078765"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.27.061406.093722"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0021-9258(19)67907-X","volume":"235","author":"Elwood J. C.","year":"1960","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1160641"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1220013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00102-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200207000-00014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-5518-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.12.037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3282f44c06"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2608"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0057"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013851"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.10.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056484"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/698256"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-72958-8_1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318182351a"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2401"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199202000-00009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.01.022"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1519\/1533-4287(2002)016<0399:POMAER>2.0.CO;2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-004-1110-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2004.06.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.01.019"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.09.047"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2003.817674"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.4.416"},{"key":"e_1_2_8_37_1","first-page":"201","volume":"85","author":"Doucet B. M.","year":"2012","journal-title":"Yale J. Biol. Med."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.020"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105045"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2015.5243"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903010110"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12370"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00623.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.04.007"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2005.10.012"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(20011215)57:4<541::AID-JBM1200>3.0.CO;2-Y"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0393"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968307313507"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20925"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.03.017"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.09.010"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200204000-00013"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.050"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227166"},{"key":"e_1_2_8_56_1","first-page":"157","volume":"23","author":"Rabkin R.","year":"1997","journal-title":"Miner. Electrolyte Metab."},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1999.tb06939.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8852"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201900535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201900535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.201900535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201900535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T03:33:40Z","timestamp":1694057620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201900535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,24]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/mnfr.201900535"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201900535","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,24]]},"assertion":[{"value":"2019-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900535"}}