{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:58:31Z","timestamp":1791885511279,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Dietary fiber (DF) induces changes in gut microbiota function and thus modulates the gut environment. How this modulation is associated with metabolic pathways related to the gut is largely unclear. This study aims to investigate differences in metabolites produced by the gut microbiota and their interactions with host metabolism in response to supplementation with two bran fibers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Male C57BL\/6N mice are fed a western diet (WD) for 17 weeks. Two groups of mice received a diet enriched with 10% w\/w of either oat or rye bran, with each bran containing 50% DF. Microbial metabolites are assessed by measuring cecal short\u2010chain fatty acids (SCFAs), ileal and fecal bile acids (BAs), and the expression of genes related to tryptophan (TRP) metabolism. Both brans lowered body weight gain and ameliorated WD\u2010induced impaired glucose responses, hepatic inflammation, liver enzymes, and gut integrity markers associated with SCFA production, altered BA metabolism, and TRP diversion from the serotonin synthesis pathway to microbial indole production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both brans develop a favorable environment in the gut by altering the composition of microbes and modulating produced metabolites. Changes induced in the gut environment by a fiber\u2010enriched diet may explain the amelioration of metabolic disturbances related to WD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201900580","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T17:19:40Z","timestamp":1591895980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Dietary Fiber from Oat and Rye Brans Ameliorate Western Diet\u2013Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short\u2010Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism"],"prefix":"10.1002","volume":"65","author":[{"given":"Zuzanna Maria","family":"Kundi","sequence":"first","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-7069","authenticated-orcid":false,"given":"Jetty Chung\u2010Yung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Pihlajam\u00e4ki","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of East Finland  Kuopio Finland"},{"name":"Clinical Nutrition and Obesity Center Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Bun","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Sum","family":"Leung","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Sik Yu","family":"So","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Nordlund","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland Ltd  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-2538","authenticated-orcid":false,"given":"Marjukka","family":"Kolehmainen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of East Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"El\u2010Nezami","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Kadoorie Building, Pokfulam The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.09.020"},{"key":"e_1_2_8_3_1","first-page":"1","author":"Fava F.","year":"2018","journal-title":"Proc. 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