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Chronic treatments with LC40 or BFM increase butyrate\u2010producing bacteria and prevent the blood pressure increase in SHR. Oral treatment with butyrate or acetate also prevents the increase in both blood pressure and Firmicutes\/Bacteroidetes (F\/B) ratio. All treatments restore the Th17\/Treg balance in mesenteric lymph nodes, normalized endotoxemia, and prevent the impairment of endothelium\u2010dependent relaxation to acetylcholine, as a result of reduced NADPH oxidase\u2010driven reactive oxygen species production. These protective effects might be mediated by both the reduction in vascular lipopolysaccharide (LPS)\/toll\u2010like receptor 4 (TLR4) pathway and the increase in Treg infiltration in the vasculature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension. These effects seem to be related to endotoxemia reduction and to increase Treg accumulation in the vasculature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900616","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T13:35:27Z","timestamp":1579354527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short\u2010Chain Fatty Acids"],"prefix":"10.1002","volume":"64","author":[{"given":"I\u00f1aki","family":"Robles\u2010Vera","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy and Center for Biomedical Research (CIBM) University of Granada  18071 Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Toral","sequence":"additional","affiliation":[{"name":"Gene Regulation in Cardiovascular Remodeling and 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