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The aim of this study is to identify the effects of goat milk consumption on glucose metabolism of rats with high\u2010fat (HF) diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty male Sprague Dawley rats are divided into five groups and fed with different diets for 24 weeks: goat\u2010milk\u2010based HF diet (GHF group; goat milk powder+HF diet), cow\u2010milk\u2010based HF diet (CHF group; cow milk powder+HF diet), HF diet, HF diet plus acarbose (HF+A group; acarbose+HF diet), and chow diet (CD group). Fasting glucose in GHF\u2010fed rats are lower than HF\u2010fed rats on weeks 16 and 20. GHF\u2010fed rats display improved insulin sensitivity in oral glucose and insulin tolerance tests. Compared with HF\u2010fed rats, glycated hemoglobin and triglycerides in GHF\u2010fed rats are lower and high\u2010density lipoprotein level is higher. AMP\u2010activated protein kinase activation (AMPK) in the liver and skeletal muscle is higher in GHF rats than HF rats. Phosphoenolpyruvate carboxykinase and glucose 6\u2010phosphatase protein levels in the liver are lower and hexokinase 2 protein level in the skeletal muscle is higher in GHF rats compared with HF rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Goat milk consumption can ameliorate abnormalities in glucose metabolism, and AMPK pathway in the liver and skeletal muscle plays an important role in the process.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900703","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T12:09:33Z","timestamp":1574338173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Goat Milk Consumption Ameliorates Abnormalities in Glucose Metabolism and Enhances Hepatic and Skeletal Muscle AMP\u2010Activated Protein Kinase Activation in Rats Fed with High\u2010Fat Diets"],"prefix":"10.1002","volume":"63","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene School of Public Health Peking University  Xueyuan Road 38 Haidian Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Sun","sequence":"additional","affiliation":[{"name":"Research and Development Department Heilongjiang Feihe Dairy Co., Ltd.  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