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This study evaluates polyphenol protective effects in cerebral endothelial cells and a mouse stroke model during hyperglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Murine bEnd.3 cerebral endothelial cells and a mouse stroke model are exposed to a characterized, polyphenol\u2010rich extract of <jats:italic>Antirhea borbonica<\/jats:italic> or its predominant constituent caffeic acid, during hyperglycemia. Polyphenol effects on redox, inflammatory and vasoactive markers, infarct volume, and hemorrhagic transformation are determined. In vitro, polyphenols improve reactive oxygen species levels, Cu\/Zn superoxide dismutase activity, and both NAPDH oxidase 4 and nuclear factor erythroid 2\u2010related factor 2 (Nrf2) gene expression deregulated by high glucose. Polyphenols reduce Nrf2 nuclear translocation and counteract nuclear factor\u2010\u0138appa B activation, interleukin\u20106 secretion, and the altered production of vasoactive markers mediated by high glucose. In vivo, polyphenols reduce cerebral infarct volume and hemorrhagic transformation aggravated by hyperglycemia. Polyphenols attenuate redox changes, increase vascular endothelial\u2010Cadherin production, and decrease neuro\u2010inflammation in the infarcted hemisphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Polyphenols protect against hyperglycemia\u2010mediated alterations in cerebral endothelial cells and a mouse stroke model. It is relevant to assess polyphenol benefits to improve cerebrovascular damages during diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900779","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T14:23:36Z","timestamp":1590330216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Protective Effects of Antioxidant Polyphenols against Hyperglycemia\u2010Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model"],"prefix":"10.1002","volume":"64","author":[{"given":"Ang\u00e9lique","family":"Arcambal","sequence":"first","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Ta\u00efl\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Couret","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"},{"name":"CHU de La R\u00e9union  Saint\u2010Pierre La R\u00e9union 97410 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Planesse","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Veeren","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Diotel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gauvin\u2010Bialecki","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union EA 2212 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Meilhac","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"},{"name":"CHU de La R\u00e9union  Saint\u2010Pierre La R\u00e9union 97410 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-409X","authenticated-orcid":false,"given":"Marie\u2010Paule","family":"Gonthier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM UMR 1188 Diab\u00e8te ath\u00e9rothrombose  Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROI)  Saint\u2010Denis La R\u00e9union 97490 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"World Health Organization Global Report on Diabetes2016 ISBN 978 92 4 156525 7."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608664"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.2.355"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00879.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017080"},{"key":"e_1_2_8_6_1","first-page":"125","volume":"2","author":"Prasad S.","year":"2014","journal-title":"J. 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