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Lipoatrophic mice are heavier than controls, severely glucose intolerant, and hyperinsulinemic, and develop NAFLD characterized by increased liver glycogen, triacylglycerol, and diacylglycerol contents, mitotic index, apoptosis, inflammation, steatosis score, fibrosis, and fatty acid synthase (FAS) content and activity. Lipoatrophic mice also display liver enrichment with monounsaturated in detriment of polyunsaturated fatty acids including n\u20103 fatty acids, and increased content of cardiolipin, a tetracyl phospholipid exclusively found at the mitochondria inner membrane. Administration of a high\u2010fat diet rich in <jats:italic>n<\/jats:italic>\u20103 fatty acids (HFO) to lipoatrophic mice enriches liver with <jats:italic>n<\/jats:italic>\u20103 fatty acids, reduces hepatic steatosis, FAS content and activity, apoptosis, inflammation, and improves glucose homeostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diet enrichment with n\u20103 fatty acids improves glucose homeostasis and reduces liver steatosis and inflammation without affecting hepatomegaly in severe lipoatrophic mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900833","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T20:24:17Z","timestamp":1579897457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lipoatrophy\u2010Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids"],"prefix":"10.1002","volume":"64","author":[{"given":"Rafael J.","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rique","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago E.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Belchior","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S.","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano B.","family":"Chaves\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara F.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janayna D.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Chemistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Chemistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mychel R. 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