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The incretin hormone glucagon\u2010like peptide\u20101 (GLP\u20101) plays a critical role in maintaining glycemic homeostasis via potentiating glucose\u2010stimulated insulin secretion and promoting \u03b2\u2010cell mass. Agents that can directly promote GLP\u20101 secretion, thereby increasing insulin secretion and preserving \u03b2\u2010cell mass, hold great potential for the treatment of T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>GluTag L\u2010cells, INS832\/13 cells, and mouse ileum crypts and islets are cultured for examining the effects of flavone hispidulin on GLP\u20101 and insulin secretion. Mouse livers and isolated hepatocytes are used for gluconeogenesis. Streptozotocin\u2010induced diabetic mice are treated with hispidulin (20 mg kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>, oral gavage) for 6 weeks to evaluate its anti\u2010diabetic potential. Hispidulin stimulates GLP\u20101 secretion from the L\u2010cell line, ileum crypts, and in vivo. This hispidulin action is mediated via activation of cyclic adenosine monophosphate\/protein kinase A signaling. Hispidulin significantly improves glycemic control in diabetic mice, concomitant with improved insulin release, and \u03b2\u2010cell survival. Additionally, hispidulin decreases hepatic pyruvate carboxylase expression in diabetic mice and suppresses gluconeogenesis in hepatocytes. Furthermore, hispidulin stimulates insulin secretion from \u03b2\u2010cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that Hispidulin may be a novel dual\u2010action anti\u2010diabetic compound via stimulating GLP\u20101 secretion and suppressing hepatic glucose production.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900978","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T01:10:19Z","timestamp":1579655419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Flavone Hispidulin Stimulates Glucagon\u2010Like Peptide\u20101 Secretion and Ameliorates Hyperglycemia in Streptozotocin\u2010Induced Diabetic Mice"],"prefix":"10.1002","volume":"64","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Human Nutrition, Foods, and Exercise, College of Agricultural and Life Sciences 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