{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:24:18Z","timestamp":1789424658094,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["RTC\u20102014\u20102401"],"award-info":[{"award-number":["RTC\u20102014\u20102401"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC\u20102017\u201021606"],"award-info":[{"award-number":["RYC\u20102017\u201021606"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Circulating dendritic cell (DC) and monocyte subsets contribute to the pool of intestinal DC and macrophages in celiac disease (CeD), an autoimmune gut disorder triggered by dietary gluten. Here, this study aims to characterize these circulating subsets in CeD and assess the effect of different gliadin\u2010derived peptides on conventional DC (cDC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Flow cytometry profiling of peripheral blood mononuclear cells reveals a slight decrease in the proportion of plasmacytoid and type 1 cDC in gluten\u2010free diet (GFD)\u2010treated CeD patients. In comparison to healthy donors, DC and monocyte subsets from active and GFD\u2010treated CeD patients display an increased gut\u2010homing profile. Type 2 cDC (cDC2) are sorted and stimulated with the gliadin\u2010derived peptides 8\u2010mer, 19\u2010mer, and 33\u2010mer. All peptides induce cDC2 maturation, although the profile is different. While peptide 8\u2010mer induces a Th1\/Th17 pro\u2010inflammatory cytokine profile in active CeD patients, cDC2 primed with peptide 33\u2010mer displays a higher capacity to promote gut\u2010homing CCR9<jats:sup>+<\/jats:sup> expression onto autologous T\u2010cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distinct gliadin\u2010derived peptides elicit different effects on cDC2 phenotype and function. This effect is compatible with a model where diverse gliadin peptides may cooperate to promote full cDC2 activation and the subsequent T\u2010cell response in genetically predisposed individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900989","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T09:14:35Z","timestamp":1579770875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Circulating Dendritic Cells from Celiac Disease Patients Display a Gut\u2010Homing Profile and are Differentially Modulated by Different Gliadin\u2010Derived Peptides"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-3101","authenticated-orcid":false,"given":"Celia","family":"Escudero\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Mucosal Immunology Laboratory, Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM) University of Valladolid\u2010CSIC  C\/ Sanz y For\u00e9s 3 47003 Valladolid Spain"},{"name":"Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Flow Cytometry facility. 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