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Supplementation with pulp significantly increases energy expenditure and reduces HF\u2010diet\u2010induced obesity and insulin resistance. The pulp, and to a lesser extent, whole polyphenols, decreases the recruitment of ATM, activation of the nod\u2010like receptor protein 3 (NLRP3) inflammasome, and adipocyte hypertrophy, which is associated with epigenetic modulation of adipogenesis (e.g., H3K27Ac, H3K9Ac). Results from an IL\u20101\u03b2 reporter assay in J774 macrophages recapitulate the inhibitory role of RR polyphenols on NLRP3 inflammasome activation. Using conditioned media from macrophages, it is demonstrated that RR polyphenols reverse the IL\u20101\u03b2\u2010mediated epigenetic suppression of H3K27Ac in adipocyte progenitor cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RR polyphenols from pulp and whole fruit serve as an inhibitor for NLRP3 inflammasome activation and an epigenetic modifier to regulate adipogenesis, which confers resistance against diet\u2010induced obesity and metabolic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201900995","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:21:50Z","timestamp":1575289310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Red Raspberry Polyphenols Attenuate High\u2010Fat Diet\u2013Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone 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