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This review examines the clinical associations of celiac disease (CeD), non\u2010celiac gluten sensitivity (NCGS), and IBD with a focus on available data of the therapeutic efficacy of gluten\u2010free diet (GFD) or low\u2010gluten\u2010containing diets in the therapy of IBD. There is a strong association between CeD and microscopic colitis, but the prevalence of CeD among IBD patients is similar to that of the general population. Interestingly, in cross\u2010sectional studies nearly one\u2010third of IBD patients report a diagnosis of NCGS, and many follow a GFD. Although animal studies have shown that gluten ingestion may promote intestinal inflammation and increase intestinal permeability, there have been no prospective studies evaluating the role of a GFD in the induction and maintenance of Crohn's disease and ulcerative colitis. Several cross\u2010sectional reports suggest that a GFD may improve symptoms in IBD patients, but due to a lack of high\u2010quality prospective clinical studies, current data do not support the universal use of a GFD in IBD.<\/jats:p>","DOI":"10.1002\/mnfr.201901274","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T12:25:45Z","timestamp":1592569545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Gluten\u2010Free Diet in IBD: Time for a Recommendation?"],"prefix":"10.1002","volume":"65","author":[{"given":"Kimberly N.","family":"Weaver","sequence":"first","affiliation":[{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases Division of Gastroenterology and Hepatology University of North Carolina  130 Mason Farm Rd 4151 Bioinformatics Buildg Chapel Hill NC 27599\u20107080 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-823X","authenticated-orcid":false,"given":"Hans","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases Division of Gastroenterology and Hepatology University of North Carolina  130 Mason Farm Rd 4151 Bioinformatics Buildg Chapel Hill NC 27599\u20107080 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"e_1_2_10_1_1","first-page":"25","volume":"7","author":"Leonard M. 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