{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:25:42Z","timestamp":1769117142766,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Since epithelial barrier dysfunction has been associated with gluten and fermentable oligosaccharide, disaccharide, monosaccharide, and polyols (FODMAPs), the effect of alterations in FODMAP a gluten intake on epithelial barrier function in patients with irritable bowel syndrome (IBS) who self\u2010reported gluten sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Circulating concentrations of markers of epithelial injury (syndecan\u20101 and intestinal fatty acid\u2010binding protein) and bacterial translocation (lipopolysaccharide\u2010binding protein and soluble CD14) are measured while consuming habitual gluten\u2010free diet and during blinded challenges with gluten or placebo on a background of low FODMAP intake. In 33 patients, only syndecan\u20101 concentrations during their habitual diet are elevated (median 43 ng mL<jats:sup>\u22121<\/jats:sup>) compared with 23 ng mL<jats:sup>\u22121<\/jats:sup>in 49 healthy subjects (<jats:italic>p<\/jats:italic>&lt; 0.001). On a low FODMAP diet, symptoms are reduced and levels of syndecan\u20101 (but not other markers) fell by a median 3335% (<jats:italic>p<\/jats:italic>&lt; 0.001) irrespective of whether gluten is present or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gluten ingestion has no specific effect on epithelial integrity or symptoms in this cohort, but reducing FODMAP intake concomitantly reduces symptoms and reverses apparent colonic epithelial injury. These findings highlight the heterogeneity of populations self\u2010reporting gluten sensitivity and implicate FODMAPs in colonic injury in IBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201901275","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T07:42:29Z","timestamp":1600328549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Gluten Ingestion and FODMAP Restriction on Intestinal Epithelial Integrity in Patients with Irritable Bowel Syndrome and Self\u2010Reported Non\u2010Coeliac Gluten Sensitivity"],"prefix":"10.1002","volume":"65","author":[{"given":"Mary","family":"Ajamian","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Monash University and Alfred Health Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Rosella","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Monash University and Alfred Health Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan D.","family":"Newnham","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Eastern Health Victoria 3128 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica R.","family":"Biesiekierski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Eastern Health Victoria 3128 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane G.","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Monash University and Alfred Health Melbourne Victoria 3004 Australia"},{"name":"Department of Gastroenterology and Hepatology Eastern Health Victoria 3128 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-1712","authenticated-orcid":false,"given":"Peter R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Monash University and Alfred Health Melbourne Victoria 3004 Australia"},{"name":"Department of Gastroenterology and Hepatology Eastern Health Victoria 3128 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064966"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.029"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8020084"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13372"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.483"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.040"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311964"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.051"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15818"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296816"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.4.837"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.70"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-245"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92390"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i47.8321"},{"key":"e_1_2_9_16_1","first-page":"177","volume":"29","author":"Palaiologou M.","year":"2014","journal-title":"Histol. 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