{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:40:03Z","timestamp":1790710803829,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K07734"],"award-info":[{"award-number":["JP16K07734"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Dietary soy reportedly protects from diabetic nephropathy (DN), but its active components and mechanism of action remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this study, KKAy mice are fed three types of diet: Dietary soy isoflavones with soy protein (Soy\u2010IP) diet, reduced isoflavones soy protein (RisoP), and oral administration of isoflavones aglycones (IsoAgc). Albuminuria and glycosuria are decreased only in the soy\u2010IP group. The risoP group show reduced expansion of mesangial matrix and renal fibrosis, the IsoAgc group show renal anti\u2010fibrotic and anti\u2010inflammatory effects; however, these renal pathological changes are repressed in the soy\u2010IP group, suggesting the distinct protective roles of soy protein or isoflavones in DN. The isoflavone genistein has a better inhibitory effect on the inflammatory response and cellular interactions in both mouse tubular cells and macrophages when exposed to high glucose and albumin (HGA). Genistein also represses HGA\u2010induced activator protein 1 activation and reactive oxidases stress generation, accompanied by reduced NADPH oxidase (NOX) gene expression. Finally, diabetic mice show a decrease in lipid peroxidation levels in both plasma and urine, along with lower NOXs gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data elucidate the detailed mechanism by which isoflavones inhibit renal inflammation and provide a potential practical adjunct therapy to restrict DN progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000015","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T07:34:35Z","timestamp":1586763275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anti\u2010Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-9273","authenticated-orcid":false,"given":"Huei\u2010Fen","family":"Jheng","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Division of Agronomy and Horticultural Science Laboratory of Quality Analysis and Assessment Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Kawada","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Seno","sequence":"additional","affiliation":[{"name":"Department of Bioinformatic Engineering Graduate School of Information Science and Technology Osaka University  Suita 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Bioinformatic Engineering Graduate School of Information Science and Technology Osaka University  Suita 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Nomura","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruya","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Laboratory of Molecular Function of Food Graduate School of Agriculture Kyoto University  Uji 611\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.17.206441"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00721.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.019398"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111210"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007091048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy197"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-25"},{"key":"e_1_2_8_9_1","first-page":"231","volume":"62","author":"Giordano C.","year":"1963","journal-title":"J. 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