{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:55Z","timestamp":1786978195086,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871118"],"award-info":[{"award-number":["81871118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Methionine restriction (MR) is known to potently alleviate inflammation and improve gut microbiome in obese mice. The gut microbiome exhibits diurnal rhythmicity in composition and function, and this, in turn, drives oscillations in host metabolism. High\u2010fat diet (HFD) strongly altered microbiome diurnal rhythmicity, however, the role of microbiome diurnal rhythmicity in mediating the improvement effects of MR on obesity\u2010related metabolic disorders remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      10\u2010week\u2010old male C57BL\/6J mice are fed a low\u2010fat diet or HFD for 4 weeks, followed with a full diet (0.86% methionine, w\/w) or a methionine\u2010restricted diet (0.17% methionine, w\/w) for 8 weeks. Analyzing microbiome diurnal rhythmicity at six time points, the results show that HFD disrupts the cyclical fluctuations of the gut microbiome in mice. MR partially restores these cyclical fluctuations, which lead to time\u2010specifically enhance the abundance of short\u2010chain fatty acids producing bacteria, increases the acetate and butyric, and dampens the oscillation of inflammation\u2010related\n                      <jats:italic>Desulfovibrionales<\/jats:italic>\n                      and\n                      <jats:italic>Staphylococcaceae<\/jats:italic>\n                      over the course of 1 day. Notably, MR, which protects against systemic inflammation, influences brain function and synaptic plasticity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MR could serve as a potential nutritional intervention for attenuating obesity\u2010induced cognitive impairments by balancing the circadian rhythm in microbiome\u2010gut\u2010brain homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202000190","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T20:55:30Z","timestamp":1596142530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Methionine Restriction Regulates Cognitive Function in High\u2010Fat Diet\u2010Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing\u2010 and Inflammation\u2010Related Microbes"],"prefix":"10.1002","volume":"64","author":[{"given":"Luanfeng","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hui","sequence":"additional","affiliation":[{"name":"BGI Institute of Applied Agriculture, BGI\u2010Shenzhen  Shenzhen 518120 China"},{"name":"Department of Food Science University of Copenhagen  Copenhagen 1958 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