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However, there are almost no studies examining their physiological function. This study aims to elucidate the physiological function of Japanese yam propagules that are heated, freeze\u2010dried, and powdered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A high\u2010fat diet with Japanese yam propagules is administered to mice for 4 weeks. High\u2010fat loading induces a decline in respiratory quotient, and a high\u2010fat diet with propagules reduces it more. This result suggests that propagules increase fat oxidation, indicating fat utilization. The hepatic transcriptome is analyzed using a DNA microarray. Some of the genes affected by high\u2010fat loading are reversed by simultaneous ingestion of propagules. Such genes are mainly involved in the immune system and fat metabolism. High\u2010fat loading induces hepatic inflammation, which is repressed by simultaneous ingestion of propagules. For lipid metabolism, propagules repress an increase in cholesterol biosynthesis and catabolism by high\u2010fat loading. Regarding carbohydrate metabolism, propagules decrease glycolysis and glycogen synthesis and increase gluconeogenesis. Moreover, amino acids are converted into pyruvate and then used for gluconeogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Propagules act to delay the occurrence of hepatic disease by suppressing carbohydrate and fat metabolism disorders in high\u2010fat loaded mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000284","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T03:56:44Z","timestamp":1596167804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Propagule Powder of Japanese Yam (<i>Dioscorea Japonica<\/i>) Reduces High\u2010Fat Diet\u2010Induced Metabolic Stress in Mice through the Regulation of Hepatic Gene Expression"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-7692","authenticated-orcid":false,"given":"Fumika","family":"Shinozaki","sequence":"first","affiliation":[{"name":"Group for Food functionality Assessment Kanagawa Institute of Industrial Science and Technology Life Science &amp; 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Environment Research Center (LiSE) 4F C\u20104  3\u201025\u201013 Tonomachi, Kawasaki\u2010ku Kawasaki Kanagawa 210\u20100821 Japan"},{"name":"Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The University of Tokyo  1\u20101\u20101 Yayoi Bunkyo\u2010ku Tokyo 113\u20108657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousuke","family":"Shimada","sequence":"additional","affiliation":[{"name":"Group for Food functionality Assessment Kanagawa Institute of Industrial Science and Technology Life Science &amp; Environment Research Center (LiSE) 4F C\u20104  3\u201025\u201013 Tonomachi, Kawasaki\u2010ku Kawasaki Kanagawa 210\u20100821 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kondo","sequence":"additional","affiliation":[{"name":"Group for Food functionality Assessment Kanagawa Institute of Industrial Science and Technology Life Science &amp; Environment Research Center (LiSE) 4F C\u20104  3\u201025\u201013 Tonomachi, Kawasaki\u2010ku Kawasaki Kanagawa 210\u20100821 Japan"},{"name":"RIKEN Tsurumi\u2010ku  1\u20107\u201022 Suehiro\u2010cho Yokohama Kanagawa 230\u20100045 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Arai","sequence":"additional","affiliation":[{"name":"Group for Food functionality Assessment Kanagawa Institute of Industrial Science and Technology Life Science &amp; 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