{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:57:13Z","timestamp":1787590633774,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010159626"],"award-info":[{"award-number":["PJT\u2010159626"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Antibiotics in early life disrupt microbiota and increase obesity risk. Dietary agents such as prebiotics may reduce obesity risk. The authors examine how antibiotics administered with\/without prebiotic oligofructose, alter metabolic and microbial outcomes in pregnant rats and their offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Pregnant rats are randomized to: 1) Control, 2) Antibiotic (ABT), 3) Prebiotic (PRE), 4) Antibiotic+Prebiotic (ABT+PRE) during the 3rd week of pregnancy and lactation. Offspring were fed a high fat\/high sucrose (HFS) diet from 9\u201317 weeks of age to unmask obesity risk. ABT dams had higher body weight, body fat and leptin during lactation than all other groups. Prebiotics attenuate these outcomes and increase cecal <jats:italic>Bifidobacterium<\/jats:italic>. ABT offspring have higher body weight, fat mass, and liver triglycerides after HFS diet, with a stronger phenotype in males; prebiotics attenuate these. At weaning, male ABT offspring have lower <jats:italic>Lactobacillus<\/jats:italic> while PRE and ABT+PRE offspring had higher <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Collinsella<\/jats:italic>. Fecal microbiota transfer of adult offspring cecal matter could not reliably transfer the obese ABT phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antibiotic use during pregnancy\/lactation increases adiposity and impairs post\u2010partum weight loss in dams. Co\u2010administering prebiotics with antibiotics in rat dams prevented obesity risk in offspring and is associated with altered gut microbiota.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000288","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T22:44:01Z","timestamp":1593643441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prebiotic Oligofructose Prevents Antibiotic\u2010Induced Obesity Risk and Improves Metabolic and Gut Microbiota Profiles in Rat Dams and Offspring"],"prefix":"10.1002","volume":"64","author":[{"given":"Teja","family":"Klancic","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary AB T2N 1N4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Laforest\u2010Lapointe","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences 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