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Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied.<\/jats:p><jats:p>Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass\u2010spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron\u2010related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation.<\/jats:p><jats:p>Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects.<\/jats:p>","DOI":"10.1002\/mnfr.202000325","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T17:53:51Z","timestamp":1593626031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice: Trace Element Status, Genomic Stability, Inflammation, and Epigenetics"],"prefix":"10.1002","volume":"64","author":[{"given":"Hannah","family":"Finke","sequence":"first","affiliation":[{"name":"Department of Food Chemistry Institute of Nutritional Science University of Potsdam Arthur\u2010Scheunert\u2010Allee 114\u2010116  Nuthetal 14558 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Winkelbeiner","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry Institute of Nutritional Science 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