{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:21Z","timestamp":1786978221536,"version":"build-2736575974"},"reference-count":137,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Previous studies have identified potent anticancer activities of polyphenols in preventing prostate cancer. The aim of the current study is to evaluate the chemopreventive potential of grape powder (GP) supplemented diets in genetically predisposed and obesity\u2010provoked prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Prostate\u2010specific\n                      <jats:italic>Pten<\/jats:italic>\n                      heterozygous (\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>+\/f<\/jats:sup>\n                      ) transgenic mice are fed low\u2010 and high\u2010fat diet (LFD and HFD, respectively) supplemented with 10% GP for 33 weeks, ad libitum. Prostate tissues are characterized using immunohistochemistry and western blots, and sera are analyzed by ELISA and qRT\u2010PCR.\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>+\/f<\/jats:sup>\n                      mice fed LFD and HFD supplemented with 10% GP show favorable histopathology, significant reduction of the proliferative rate of prostate epithelial cells (Ki67), and rescue of PTEN expression. The most potent protective effect of GP supplementation is detected against HFD\u2010induced increase in inflammation (IL\u20101\u03b2; TGF\u2010\u03b21), activation of cell survival pathways (Akt, AR), and angiogenesis (CD31) in\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>+\/f<\/jats:sup>\n                      mice. Moreover, GP supplementation reduces circulating levels of oncogenic microRNAs (miR\u201034a; miR\u201022) in\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>+\/f<\/jats:sup>\n                      mice. There are no significant changes in body weight and food intake in GP supplemented diet groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GP diet supplementation can be a beneficial chemopreventive strategy for obesity\u2010related inflammation and prostate cancer progression. Monitoring serum miRNAs can facilitate the non\u2010invasive evaluation of chemoprevention efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202000326","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T23:33:58Z","timestamp":1593732838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Grape Powder Supplementation Attenuates Prostate Neoplasia Associated with\n                    <i>Pten<\/i>\n                    Haploinsufficiency in Mice Fed High\u2010Fat Diet"],"prefix":"10.1002","volume":"64","author":[{"given":"Tanvi","family":"Joshi","sequence":"first","affiliation":[{"name":"Arnold &amp; Marie Schwartz College of Pharmacy and Health Sciences Long Island University  Brooklyn NY 11201 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishani","family":"Patel","sequence":"additional","affiliation":[{"name":"Arnold &amp; Marie Schwartz College of Pharmacy and Health Sciences Long Island University  Brooklyn NY 11201 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Arnold &amp; 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