{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:32:32Z","timestamp":1777343552661,"version":"3.51.4"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The aim of this study is to test whether the choice of the lipid emulsion in total parenteral nutrition (TPN), that is, n\u20103 fatty acid\u2010based Omegaven versus n\u20106 fatty acid\u2010based Intralipid, determines inflammation in the liver, the incretin profile, and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Jugular vein catheters (JVC) are placed in C57BL\/6 mice and used for TPN for 7 days. Mice are randomized into a saline group (saline infusion with oral chow), an Intralipid group (IL\u2010TPN, no chow), an Omegaven group (OV\u2010TPN, no chow), or a chow only group (without JVC). Both TPN elicite higher abundance of lipopolysaccharide binding protein in the liver, but only IL\u2010TPN increases interleukin\u20106 and interferon\u2010\u03b3, while OV\u2010TPN reduces interleukin\u20104, monocyte chemoattractant protein\u20101, and interleukin\u20101\u03b1. Insulin plasma concentrations are higher in both TPN, while glucagon and glucagon\u2010like peptide\u20101 (GLP\u20101) were higher in IL\u2010TPN. Gluconeogenesis is increased in IL\u2010TPN and the nuclear profile of key metabolic transcription factors shows a liver\u2010protective phenotype in OV\u2010TPN. OV\u2010TPN increases insulin sensitivity in the liver and skeletal muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OV\u2010TPN as opposed to IL\u2010TPN mitigates inflammation in the liver and reduces the negative metabolic effects of hyperinsulinemia and hyperglucagonemia by \u201cre\u2010sensitizing\u201d the liver and skeletal muscle to insulin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000412","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T15:49:42Z","timestamp":1596124182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Choice of Lipid Emulsion Determines Inflammation of the Gut\u2010Liver Axis, Incretin Profile, and Insulin Signaling in a Murine Model of Total Parenteral Nutrition"],"prefix":"10.1002","volume":"65","author":[{"given":"Phing\u2010How","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Alberta  Edmonton T6G 2R3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Lucchinetti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine and Cardiovascular Research Centre University of Alberta  Edmonton T6G 2R3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Wawrzyniak","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry and Biochemistry University Children's Hospital Zurich  Zurich 8032 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich and University of Zurich  Zurich 8091 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