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Kidney is a vital organ in managing water reabsorption and glucose metabolism, and is greatly influenced by diabetes. The present study investigates the effects of tea administration on water reabsorption and gluconeogenesis in the kidney of diabetic mice.<\/jats:p><jats:p>Methods and results: Db\/db mice are given tea infusion as drinking fluid when they begin to exhibit hyperglycemia. It is found that green tea or black tea infusion potently elevates renal proteins vital for water reabsorption, including protein kinase C\u2010\u03b1, aquaporin 2, and urea transporter\u2010A1, as well as increases trafficking of these proteins to apical plasma membrane where they exert water reabsorption function. The treatment also downregulates renal gluconeogenic enzymes, including glucose\u20106\u2010phosphatase\u2010\u03b1 and phosphoenolpyruvate carboxykinase. Associated with these biochemical changes are the rectified polyuria, polydipsia, polyphagia, and hyperglycemia, all symptoms of diabetes.<\/jats:p><jats:p>Conclusions: For the first time, the present study demonstrates that tea has robust effects in enhancing kidney water reabsorption proteins and downregulating gluconeogenic enzymes in db\/db mice. It remains to be investigated whether such beneficial effects of tea occur in humans.<\/jats:p>","DOI":"10.1002\/mnfr.202000505","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:27:43Z","timestamp":1602635263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tea Drinking Alleviates Diabetic Symptoms via Upregulating Renal Water Reabsorption Proteins and Downregulating Renal Gluconeogenic Enzymes in db\/db Mice"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-2597","authenticated-orcid":false,"given":"Guangshan","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization School of Tea &amp; Food Science Anhui Agricultural University  Hefei Anhui 230036 China"},{"name":"Biology Postdoctoral Research Station Department of Cell Biology College of Life Science and Technology Jinan University  Guangzhou Guangdong 510632 China"},{"name":"Guangzhou Jinan Biomedicine Research and Development Center Institute of Biomedicine College of Life Science and Technology Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximing","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization School of Tea &amp; Food Science Anhui Agricultural University  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization School of Tea &amp; Food Science Anhui Agricultural University  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of 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