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However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well\u2010known risk factor for CVD while hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), a product of its metabolism, has been proved to exert opposite effects to Hcy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>First, it is investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H<jats:sub>2<\/jats:sub>S synthesis of the progeny. Carbohydrates are supplied to pregnant rats in drinking water (10% wt\/vol) throughout gestation. Adult female descendants from fructose\u2010fed, control or glucose\u2010fed mothers are studied. Females from fructose\u2010fed mothers have elevated homocysteinemia, hepatic H<jats:sub>2<\/jats:sub>S production, cystathionine \u03b3\u2010lyase (CSE) (the key enzyme in H<jats:sub>2<\/jats:sub>S synthesis) expression and plasma H<jats:sub>2<\/jats:sub>S, versus the other two groups. Second, it is studied how adult female progeny from control (C\/F), fructose\u2010 (F\/F), and glucose\u2010fed (G\/F) mothers responded to liquid fructose and compared them to the control group (C\/C). Interestingly, hepatic CSE expression and H<jats:sub>2<\/jats:sub>S synthesis are diminished by fructose intake, this effect being more pronounced in F\/F females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal fructose intake produces a fetal programming that increases hepatic H<jats:sub>2<\/jats:sub>S production and, in contrast, exacerbates its fructose\u2010induced drop in female progeny.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000628","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T02:54:50Z","timestamp":1596596090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal Fructose Intake Increases Liver H<sub>2<\/sub>S Synthesis but Exarcebates its Fructose\u2010Induced Decrease in Female Progeny"],"prefix":"10.1002","volume":"64","author":[{"given":"Elena","family":"Fauste","sequence":"first","affiliation":[{"name":"Facultad 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