{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:02:46Z","timestamp":1759683766030,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Accumulating evidence indicates that micronutrients are related to metabolic diseases. However, comparatively less attention has been devoted to their influence on each other during the development of metabolic diseases. To investigate the underlying mechanisms, the effects of iron and vitamin D on pancreatic \u03b2 cell functions are examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Iron overload is induced in INS\u20101 rat insulinoma pancreatic \u03b2 cells and it is found that iron overload dramatically reduce expression of the vitamin D receptor (VDR). Iron overload\u2010induced \u03b2 cell dysfunction is rescued by 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) cotreatment via restoration of VDR level and the consequent maintenance of Ca<jats:sup>2+<\/jats:sup> homeostasis. Iron accumulation is also observed in the islets of 22\u2010month\u2010old C57BL\/6 mice fed with a chow diet (1000 IU vitamin D<jats:sub>3<\/jats:sub> per kg). In contrast, islet iron accumulation and hyperinsulinemia are ameliorated in mice fed with a vitamin D<jats:sub>3<\/jats:sub>\u2010supplemented diet (20\u00a0000\u00a0IU kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The authors show that functional failure of \u03b2 cells due to iron accumulation is rescued by 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, and iron overload significantly reduces VDR levels in \u03b2 cells. These results suggest that iron and vitamin D inversely influence pancreatic \u03b2 cell function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000772","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T06:29:57Z","timestamp":1608100197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D Rescues Pancreatic \u03b2 Cell Dysfunction due to Iron Overload via Elevation of the Vitamin D Receptor and Maintenance of Ca<sup>2+<\/sup> Homeostasis"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-9135","authenticated-orcid":false,"given":"Yoo Jeong","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrine and Kidney Disease Research Department of Chronic Disease Convergence Research Korea National Institute of Health Cheongju 28159 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Kidney Disease Research Department of Chronic Disease Convergence Research Korea National Institute of Health Cheongju 28159 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ick","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Kidney Disease Research Department of Chronic Disease Convergence Research Korea National Institute of Health Cheongju 28159 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Kidney Disease Research Department of Chronic Disease Convergence Research Korea National Institute of Health Cheongju 28159 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2013"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075250"},{"key":"e_1_2_7_4_1","first-page":"513","volume":"2","author":"Fern\u00e1ndez\u2010Real J. 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