{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:24:12Z","timestamp":1772079852442,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0210200"],"award-info":[{"award-number":["E0210200"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1A2C2012608"],"award-info":[{"award-number":["NRF\u20102020R1A2C2012608"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Advanced glycation end products (AGEs) and receptor of advanced glycation end products (RAGE) mediate renal function during diabetic and non\u2010diabetic nephropathy development. Methylglyoxal\u2010lysine dimer (MOLD), a typical toxic advanced glycation end product (TAGE), contributes to inflammatory responses during renal diseases. This study determines the effect of MOLD on inflammatory responses in mouse mesangial cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The murine mesangial cell line SV40 MES 13 is used to assess nuclear factor\u2010kappa B (NF\u2010\u03baB) expression, reactive oxygen species (ROS) production, and mitochondria labeling. The interaction model between RAGE and MOLD is also determined. MOLD treatment of mesangial cells markedly increases RAGE expression and the linkage with V\u2010type Ig domain of RAGE. MOLD induces ROS production and mitochondrial dysfunction. MOLD activates phosphatidylinositol 3\u2010kinase\u2010protein kinase B (PI3KB) and NF\u2010\u03baB signaling pathways. It is confirmed that these changes are reversed when ROS is suppressed. These effects may be regulated through mitogen\u2010activated protein kinases and pro\u2010inflammatory cytokines in circulatory inflammation responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MOLD plays a major role in nephropathy via ROS production and mitochondrial dysfunction through direct association with RAGE. Further, the NF\u2010kB and PI3K\/AKT signaling pathways triggered by ROS mediate the inflammatory response to exacerbate MOLD\u2010induced damages in inflammation\u2010related diabetic and non\u2010diabetic renal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000799","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T13:49:40Z","timestamp":1619185780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Methylglyoxal\u2010Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells"],"prefix":"10.1002","volume":"65","author":[{"given":"Hee\u2010Weon","family":"Lee","sequence":"first","affiliation":[{"name":"Korea Food Research Institute  245, Nongsaengmyeong\u2010ro, Iseo\u2010myeon, Wanju\u2010gun Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ji","family":"Gu","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute  245, Nongsaengmyeong\u2010ro, Iseo\u2010myeon, Wanju\u2010gun Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Molecular Design Team, New Drug Development Center Daegu Gyeongbuk Medical Innovation Foundation (DGMIF)  Daegu 41061 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungju","family":"Lee","sequence":"additional","affiliation":[{"name":"Molecular Design Team, New Drug Development Center Daegu Gyeongbuk Medical Innovation Foundation (DGMIF)  Daegu 41061 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonsook","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute  245, Nongsaengmyeong\u2010ro, Iseo\u2010myeon, Wanju\u2010gun Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-2279","authenticated-orcid":false,"given":"Sang Keun","family":"Ha","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute  245, Nongsaengmyeong\u2010ro, Iseo\u2010myeon, Wanju\u2010gun Jeollabuk\u2010do 55365 Republic of Korea"},{"name":"Division of Food Biotechnology University of Science and Technology  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900934"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.01.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-015-1851-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods5040084"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081748"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02317.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27414"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050178"},{"key":"e_1_2_9_10_1","first-page":"191","volume-title":"Oxidative Stress and Inflammation in Non\u2010communicable Diseases\u2010Molecular Mechanisms and Perspectives in Therapeutics","author":"Gugliucci A.","year":"2014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.5.E685"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.243"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.01.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156037"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201511036"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.034"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00367.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1455-y"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.429"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302281"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.07.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-011-0198-7"},{"key":"e_1_2_9_24_1","first-page":"307","volume":"11","author":"Ji J. 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