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This study is aimed to explore the influence of the WD on chronic liver disease (CLD) and its possible mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6 mice are given a control diet (CD) or WD and CLD is induced by intraperitoneally injecting carbon tetrachloride (CCL<jats:sub>4<\/jats:sub>) twice a week for 8 weeks. The WD aggravated CCL<jats:sub>4<\/jats:sub>\u2010induced chronic liver injury, as evidenced by increased serum transaminase levels, worsened hepatic inflammatory response, and fibrosis. Gut microbiota is disturbed in mice treated with CCL<jats:sub>4<\/jats:sub>+WD (WC group), manifested as the accumulation of Fusobacteria, <jats:italic>Streptococcaceae<\/jats:italic>, <jats:italic>Streptococcus<\/jats:italic>, <jats:italic>Fusobacterium<\/jats:italic>, and <jats:italic>Prevotella<\/jats:italic> and the depletion of <jats:italic>Firmicutes<\/jats:italic>, <jats:italic>Lachnospiraceae<\/jats:italic>, and <jats:italic>Roseburia<\/jats:italic>. Additionally, increased hepatic taurocholic acid in the WC group activated sphingosine\u20101\u2010phosphate receptor 2, which is positively correlated with hepatic fibrosis and inflammation parameters. Mice in the WC group have higher fecal primary bile acid (BA) levels and lower fecal secondary\/primary BA ratios. Serum FGF15 levels are also elevated in the WC group, which is positively correlated with hepatic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WD accelerates the progression of CLD which is associated with changes in the gut microbiota and BA metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000811","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T08:01:46Z","timestamp":1610956906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Western Diet Aggravated Carbon Tetrachloride\u2010Induced Chronic Liver Injury by Disturbing Gut Microbiota and Bile Acid Metabolism"],"prefix":"10.1002","volume":"65","author":[{"given":"Liya","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou 310003 P. 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