{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:36Z","timestamp":1753869756183,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Nutritional supplementation of the maternal diet can modify the cancer susceptibility in adult offspring. Therefore, the authors evaluate the effects of a fish\u2010oil diet administered to a long\u2010term, during pre\u2010mating, gestation, and lactation, in reducing cancer\u2010cachexia damages in adult Walker\u2010256 tumor\u2010bearing offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Female rats receive control or fish oil diet during pre\u2010mating, gestation, and lactation. After weaning, male offspring are fed the control diet until adulthood and distributed in (C) control adult\u2010offspring; (W) adult tumor\u2010bearing offspring; (OC) adult\u2010offspring of maternal fish oil diet; (WOC) adult tumor\u2010bearing offspring of maternal fish oil diet groups. Fat body mass is preserved, muscle expression of mechanistic target of rapamicin (mTOR) and eukariotic binding protein of eukariotic factor 4E (4E\u2010BP1) is modified, being associated with lower 20S proteasome protein expression, and the liver alanine aminotransferase (ALT) enzyme content maintained in the WOC group. Also, the OC group shows reduced triglyceridemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this experimental model of cachexia, the long\u2010term maternal supplementation is a positive strategy to improve liver function and lipid metabolism, as well as to modify muscle proteins expression in the mTOR pathway and also reduce the 20S muscle proteasome protein, without altering the tumor development and muscle wasting in adult tumor\u2010bearing offspring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000863","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T15:20:23Z","timestamp":1614698423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fish Oil Diet during Pre\u2010mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-7741","authenticated-orcid":false,"given":"Sarah Christine Pereira de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Angelo da Silva","family":"Miyaguti","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Thomas","family":"Russell","sequence":"additional","affiliation":[{"name":"School of Bioscience, College of Health and Life Sciences Aston University  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"Tobar","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Vieira","family":"Geraldo","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Cell Biology, Department of Structural and Functional Biology, Biology Institute University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-756X","authenticated-orcid":false,"given":"Maria Cristina Cintra","family":"Gomes\u2010Marcondes","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"journal-title":"Nat. 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