{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:09:30Z","timestamp":1768518570124,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Degraded porphyran is a bioactive polysaccharide extracted from<jats:italic>Porphyra haitanensis<\/jats:italic>(<jats:italic>P. haitanensis<\/jats:italic>). According to the previous studies, it produced anti\u2010inflammatory activity, but little is known about its effects on depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>As inflammation is one of the critical factors involved in the development of depression, this study aims to elucidate the potential antidepressant\u2010like effects of degraded porphyran. The results show that acute porphyran treatment decreased the immobility time in despair tests. In addition, subchronic porphyran administration reverses depressive\u2010like behaviors in lipopolysaccharide (LPS)\u2010treated mice. Meanwhile, porphyran inhibits NF\u2010\u03baB\/NLRP3 signaling, proinflammatory cytokine release, and microglial activation in the hippocampus. Moreover, chronic porphyran treatment activates hippocampal brain derived neurotrophic factor (BDNF)\/TrkB\/ERK\/CREB signaling pathway in chronic unpredictable mild stress (CUMS) in mice. As a result, neurogenesis and spinogenesis are maintained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study indicate that degraded porphyran intake provides a potential strategy for depression treatment, which is mediated by the inhibition of neuroinflammation and the enhancement of neurogenesis and spinogenesis in the central nervous systems.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000869","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T09:47:28Z","timestamp":1617097648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antidepressant\u2010like Effects of Degraded Porphyran Isolated from<i>Porphyra haitanensis<\/i>"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-8607","authenticated-orcid":false,"given":"Li\u2010Tao","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering College of Chemical Engineering Huaqiao University Xiamen Fujian Province 361021 PR China"},{"name":"Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao University Xiamen Fujian Province 361021 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man\u2010Man","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering College of Chemical Engineering Huaqiao University Xiamen Fujian Province 361021 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering College of Chemical Engineering Huaqiao University Xiamen Fujian Province 361021 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Qi","family":"Wan","sequence":"additional","affiliation":[{"name":"Xiamen Medicine Research Institute Xiamen Fujian Province 361008 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Fu","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen Hospital of Traditional Chinese Medicine Xiamen Fujian Province 361009 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Xiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Traditional Chinese Medicine Nanchang Jiangxi Province 330004 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiamen Hospital of Traditional Chinese Medicine Xiamen Fujian Province 361009 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering College of Chemical Engineering Huaqiao University Xiamen Fujian Province 361021 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Xiamen Medicine Research Institute Xiamen Fujian Province 361008 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/13811118.2019.1691692"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.03.006"},{"key":"e_1_2_9_3_1","volume-title":"Institute for Quality and Efficiency in Health Care (IQWiG)","author":"Cologne G.","year":"2020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/34.6.705"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2009.03.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9954"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.05.146"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115811"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115457"},{"key":"e_1_2_9_10_1","first-page":"39","volume":"3","author":"Wang W.","year":"2015","journal-title":"Ann. 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