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Although there are multiple health benefits of a vegan diet, studies have also linked the diet with deficiencies in various micronutrients. This study focuses on vitamin B<jats:sub>12,<\/jats:sub> because of its critical role in DNA synthesis and methylation. In light of these connections, a critical review of recent scientific literature is conducted to understand the effects of a B<jats:sub>12<\/jats:sub> deficient diet on the genome and epigenome, and whether it can give rise to cancer. It is observed that a B<jats:sub>12<\/jats:sub> deficiency leads to increased uracil misincorporation, leading to impaired DNA synthesis and genomic instability. The deficiency also leads to global hypomethylation of DNA, a hallmark of early carcinogenesis. The findings of this study highlight the need for increased awareness among vegans to ensure adequate B<jats:sub>12<\/jats:sub> intake through supplementation or consumption of fortified products as a preventative measure. Additionally, the biofortification of staple crops and an improved version of fermented products with increased B<jats:sub>12<\/jats:sub> content can be developed when inadequate intake seems otherwise inevitable.<\/jats:p>","DOI":"10.1002\/mnfr.202000945","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T13:52:52Z","timestamp":1612619572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is There a Carcinogenic Risk Attached to Vitamin B<sub>12<\/sub> Deficient Diets and What Should We Do About It? Reviewing the Facts"],"prefix":"10.1002","volume":"65","author":[{"given":"Alexandra K.","family":"Loedin","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Medical Biochemistry University of Amsterdam  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-2753","authenticated-orcid":false,"given":"Dave","family":"Speijer","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Medical Biochemistry University of Amsterdam  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"e_1_2_12_1_1","unstructured":"Merriam\u2010Webster vegan. Merriam\u2010Webster.com 2020.https:\/\/www.merriam\u2010webster.com\/dictionary\/vegan"},{"key":"e_1_2_12_2_1","unstructured":"L.Oberst Why the Global Rise in Vegan and Plant\u2010Based Eating Isn't A Fad. 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