{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:06:20Z","timestamp":1784919980963,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Scope<\/jats:title><jats:p>To examine the effects of myo\u2010inositol supplementation during lactation in male and female rats on metabolic parameters and its potential to reverse metabolic alterations associated with a moderate gestational calorie restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The offspring of control and 25% gestational calorie\u2010restricted rats are supplemented with myo\u2010inositol or vehicle throughout lactation and exposed to a Western diet (WD) from 5 to 7 months of age. Blood parameters are measured and gene expression and protein levels in retroperitoneal white adipose tissue (rWAT) and liver are analyzed. In male offspring, but not in females, myo\u2010inositol supplementation resulted in lower fasting triglyceride and insulin levels and HOMA\u2010IR at 7 months, and reversed the alterations in these parameters due to gestational calorie restriction. The expression pattern of key genes in metabolism in rWAT and liver support the beneficial effect of myo\u2010inositol supplementation in reversing metabolic alterations programmed by gestational calorie restriction in male rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Myo\u2010inositol supplementation at physiological doses during lactation improves metabolic health and prevents the programmed trend to develop insulin resistance and hypertriglyceridemia in male rats acquired by inadequate fetal nutrition and exacerbated by a diabetogenic diet in adulthood. The absence of clear effects in females deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000965","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T06:50:14Z","timestamp":1612767014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sex\u2010Specific Effects of Myo\u2010Inositol Ingested During Lactation in the Improvement of Metabolic Health in Adult Rats"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-6829","authenticated-orcid":false,"given":"Pedro","family":"Castillo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN)  Palma Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Palou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN)  Palma Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Otero","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Palou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN)  Palma Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Pic\u00f3","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands  Palma Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN)  Palma Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040367"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340779"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00436"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00764"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.874S"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.1.E83"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-69"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.11.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2461"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08837-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803260"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.027284"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.155"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803585"},{"key":"e_1_2_9_15_1","first-page":"875","volume":"76","author":"Palou M.","year":"2018","journal-title":"Nutr. 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