{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:27:40Z","timestamp":1772605660286,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010781","name":"Diabetes-Stiftung","doi-asserted-by":"publisher","award":["232\/11\/08"],"award-info":[{"award-number":["232\/11\/08"]}],"id":[{"id":"10.13039\/100010781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The Optimal Fibre Trial (OptiFiT) investigates metabolic effects of insoluble cereal fibre in subjects with impaired glucose tolerance (IGT), showing moderate glycemic and anti\u2010inflammatory benefits, especially in subjects with an obesity\u2010related phenotype. An OptiFiT sub\u2010group is analysed for effects on body fat distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>180 participants with IGT receive a blinded, randomized supplementation with insoluble cereal fibre or placebo for 2 years. Once a year, all subjects undergo fasting blood sampling, oral glucose tolerance test, and anthropometric measurements. A subgroup (n=47) also received magnetic resonance imaging and spectroscopy for quantification of adipose tissue distribution and liver fat content. We compared MR, metabolic and inflammatory outcomes between fibre and placebo group metabolism and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Visceral and non\u2010visceral fat, fasting glucose, HbA1c, fasting insulin, insulin resistance, and uric acid decrease only in the fibre group, mirroring effects of the entire cohort. However, after adjustment for weight loss, there are no significant between\u2010group differences. There is a statistical trend for fibre\u2010driven liver fat reduction in subjects with confirmed non\u2010alcoholic fatty liver disease (NAFLD; <jats:italic>n<\/jats:italic>\u00a0= 19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data and evidence on beneficial effects of insoluble cereal fibre on visceral and hepatic fatstorage is limited, but warrants further research. Targeted trials are required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202000991","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:32:59Z","timestamp":1619656379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Insoluble Cereal Fibre on Body Fat Distribution in the Optimal Fibre Trial"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-1757","authenticated-orcid":false,"given":"Stefan","family":"Kabisch","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"},{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung e.V. Gesch\u00e4ftsstelle am Helmholtz\u2010Zentrum M\u00fcnchen  Ingolst\u00e4dter Landstra\u00dfe 1 Neuherberg 85764 Germany"},{"name":"Department of Endocrinology, Diabetes and Nutrition Campus Benjamin Franklin Charit\u00e9 University Medicine  Hindenburgdamm 30 Berlin 12203 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Honsek","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margrit","family":"Kemper","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"},{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung e.V. 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Gesch\u00e4ftsstelle am Helmholtz\u2010Zentrum M\u00fcnchen  Ingolst\u00e4dter Landstra\u00dfe 1 Neuherberg 85764 Germany"},{"name":"Department of Endocrinology, Diabetes and Nutrition Campus Benjamin Franklin Charit\u00e9 University Medicine  Hindenburgdamm 30 Berlin 12203 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman M.","family":"Arafat","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"},{"name":"Department of Endocrinology, Diabetes and Nutrition Campus Benjamin Franklin Charit\u00e9 University Medicine  Hindenburgdamm 30 Berlin 12203 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas L.","family":"Birkenfeld","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung e.V. Gesch\u00e4ftsstelle am Helmholtz\u2010Zentrum M\u00fcnchen  Ingolst\u00e4dter Landstra\u00dfe 1 Neuherberg 85764 Germany"},{"name":"Department of Internal Medicine IV Division of Diabetology, Endocrinology and Nephrology Eberhard\u2010Karls University T\u00fcbingen  Otfried\u2010M\u00fcller\u2010Str. 10 T\u00fcbingen 72076 Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  Otfried\u2010M\u00fcller\u2010Str. 10 T\u00fcbingen 72076 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Machann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Division of Diabetology, Endocrinology and Nephrology Eberhard\u2010Karls University T\u00fcbingen  Otfried\u2010M\u00fcller\u2010Str. 10 T\u00fcbingen 72076 Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  Otfried\u2010M\u00fcller\u2010Str. 10 T\u00fcbingen 72076 Germany"},{"name":"Department of Radiology Section on Experimental Radiology University of T\u00fcbingen  Otfried\u2010M\u00fcller\u2010Str. 51 T\u00fcbingen 72076 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Dambeck","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Osterhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 Nuthetal 14558 Germany"},{"name":"Department of Endocrinology, Diabetes and Nutrition Campus Benjamin Franklin Charit\u00e9 University Medicine  Hindenburgdamm 30 Berlin 12203 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin O.","family":"Weickert","sequence":"additional","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism The ARDEN NET Centre ENETS CoE University Hospitals Coventry and Warwickshire NHS Trust  Coventry CV2 2DX UK"},{"name":"Centre of Applied Biological &amp; Exercise Sciences (ABES) Faculty of Health &amp; Life Sciences Coventry University  Coventry CV1 5FB UK"},{"name":"Translational &amp; Experimental Medicine Division of Biomedical Sciences Warwick Medical School University of Warwick  Coventry CV4 7AL UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas F. 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