{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:38:05Z","timestamp":1791239885269,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD080201"],"award-info":[{"award-number":["HD080201"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD089989"],"award-info":[{"award-number":["HD089989"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1046203"],"award-info":[{"award-number":["OPP1046203"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Iron deficiency (ID) compromises the health of infants worldwide. Although readily treated with iron, concerns remain about the persistence of some effects. Metabolic and gut microbial consequences of infantile ID were investigated in juvenile monkeys after natural recovery (pID) from iron deficiency or post\u2010treatment with iron dextran and B vitamins (pID+Fe).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Metabolomic profiling of urine and plasma is conducted with <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR) spectroscopy. Gut microbiota are characterized from rectal swabs by amplicon sequencing of the 16S rRNA gene. Urinary metabolic profiles of pID monkeys significantly differed from pID+Fe and continuously iron\u2010sufficient controls (IS) with higher maltose and lower amounts of microbial\u2010derived metabolites. Persistent differences in energy metabolism are apparent from the plasma metabolic phenotypes with greater reliance on anaerobic glycolysis in pID monkeys. Microbial profiling indicated higher abundances of <jats:italic>Methanobrevibacter<\/jats:italic>, <jats:italic>Lachnobacterium<\/jats:italic>, and <jats:italic>Ruminococcus<\/jats:italic> in pID monkeys and any history of ID resulted in a lower <jats:italic>Prevotella<\/jats:italic> abundance compared to the IS controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lingering metabolic and microbial effects are found after natural recovery from ID. These long\u2010term biochemical derangements are not present in the pID+Fe animals emphasizing the importance of the early detection and treatment of early\u2010life ID to ameliorate its chronic metabolic effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202001018","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T05:42:37Z","timestamp":1613626957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gut Microbial and Metabolic Profiling Reveal the Lingering Effects of Infantile Iron Deficiency Unless Treated with Iron"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-3815","authenticated-orcid":false,"given":"Jordi","family":"Mayneris\u2010Perxachs","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Josep Trueta University Hospital  Girona Spain"},{"name":"Nutrition, Eumetabolism and Health Group Girona Biomedical Research Institute (IdibGi)  Girona Spain"},{"name":"Obesity and Nutrition  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Amaral","sequence":"additional","affiliation":[{"name":"Harlow Center for Biological Psychology University of Wisconsin  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele R.","family":"Lubach","sequence":"additional","affiliation":[{"name":"Harlow Center for Biological Psychology University of Wisconsin  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lyte","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Iowa State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Iowa State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joram M.","family":"Posma","sequence":"additional","affiliation":[{"name":"Department of Metabolism, DigCIBER in Physiopathology of estion and Reproduction Imperial College London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Coe","sequence":"additional","affiliation":[{"name":"Harlow Center for Biological Psychology University of Wisconsin  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-4529","authenticated-orcid":false,"given":"Jonathan R.","family":"Swann","sequence":"additional","affiliation":[{"name":"Department of Metabolism, DigCIBER in Physiopathology of estion and Reproduction Imperial College London  UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton  UK"},{"name":"Department of Neuroscience Karolinska Institute  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"C.Camaschella Review Series IRON METABOLISM AND ITS DISORDERS Iron Deficiency2019."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-815894"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050632"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.11.017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.9.2345"},{"key":"e_1_2_9_6_1","author":"Sandri B. 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