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Body weight and food intake are monitored weekly. Obesity\u2010related biochemical indexes and the expression levels of genes related to lipid metabolism are determined. Amplicon sequencing of the bacterial 16S rRNA gene is conducted to analyze the gut microbiota structure, and spearman correlation analysis is used to determine the correlations between gut microbiota and obesity\u2010related indicators. The results showed that BCA treatment alleviated HFD\u2010induced obesity, hyperlipemia, and hepatic steatosis. Moreover, BCA supplement improved hepatic lipid metabolism by regulating the expression of genes related to the synthesis and degradation of lipids and cholesterols. Microbial analysis revealed that BCA supplementation significantly changed the overall structure and composition of the gut microbiota, and resulted in an enrichment of <jats:italic>Akkermansia_muciniphila<\/jats:italic>, which is negatively correlated with the physical biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that BCA supplement could be a beneficial treatment for preventing HFD\u2010induced obesity by targeting microbiota.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202001090","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T15:45:03Z","timestamp":1612885503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Black Current Anthocyanins Improve Lipid Metabolism and Modulate Gut Microbiota in High\u2010Fat Diet\u2010Induced Obese Mice"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-3084","authenticated-orcid":false,"given":"Haizhao","family":"Song","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Collaborative Innovation Center for Modern Grain Circulation and Safety\/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and Economics  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-1587","authenticated-orcid":false,"given":"Xinchun","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Collaborative Innovation Center for Modern Grain Circulation and Safety\/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and Economics  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Collaborative Innovation Center for Modern Grain Circulation and Safety\/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and Economics  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Collaborative Innovation Center for Modern Grain Circulation and Safety\/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and Economics  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01081-X"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00240-9"},{"key":"e_1_2_9_3_1","first-page":"e1900482","author":"Curley S.","year":"2020","journal-title":"Mol. 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