{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:25Z","timestamp":1792597525491,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Perinatal high\u2010fat (HF) diet induces hypertension in adult offspring. Garlic, a naturally dietary source of Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) donor, has been shown benefits in hypertension. The article examines whether maternal garlic oil supplementation can prevent hypertension induced by HF diet and elucidate its protective effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Pregnant rats are given either a normal diet or HF diet. Rat dams are given garlic oil or vehicle daily by oral gavage at 100\u00a0mg kg<jats:sup>\u20101<\/jats:sup> day<jats:sup>\u20101<\/jats:sup> during pregnancy and lactation. Male offspring are sacrificed at 16 weeks of age. Garlic oil supplementation during pregnancy and lactation protected against hypertension induced by HF diet in adult male offspring. The beneficial effects of garlic oil are associated with increased renal mRNA expression and activity of H<jats:sub>2<\/jats:sub>S\u2010generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition. Garlic oil supplementation increases abundance of genus Lactobacillus, but decreases genera Turicibacter and Staphylococcus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data reveals associations between H<jats:sub>2<\/jats:sub>S\u2010generating pathway in the gut and kidneys, NO system, gut microbiota, and microbiota\u2010derived metabolites in hypertension induced by HF intake and provide insight to garlic oil as a hypertension reprogramming strategy for further translational research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202001116","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T11:40:07Z","timestamp":1612611607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Maternal Garlic Oil Supplementation Prevents High\u2010Fat Diet\u2010Induced Hypertension in Adult Rat Offspring: Implications of H2S\u2010Generating Pathway in the Gut and Kidneys"],"prefix":"10.1002","volume":"65","author":[{"given":"Chien\u2010Ning","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"School of Pharmacy Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Seafood Science National Kaohsiung University of Science and Technology  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Ping","family":"Chang\u2010Chien","sequence":"additional","affiliation":[{"name":"Center for Environmental Toxin and Emerging\u2010Contaminant Research Cheng Shiu University  Kaohsiung Taiwan"},{"name":"Super Micro Mass Research and Technology Center Cheng Shiu University  Kaohsiung 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