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Drugs were treated for 12 weeks. LBP.L significantly reduces the salivary gland inflammation compared with the control group (histological score <jats:italic>p<\/jats:italic> <jats:sub>LBP.L<\/jats:sub> vs <jats:sub>Control<\/jats:sub>\u00a0=\u00a00.019; foci number: <jats:italic>p<\/jats:italic> <jats:sub>LBP.L<\/jats:sub> vs <jats:sub>Control<\/jats:sub>\u00a0=\u00a00.038). LBP.L also remarkably reduces the effector follicular helper T (Tfh) cells and the CD4<jats:sup>+<\/jats:sup>IL\u201017A<jats:sup>+<\/jats:sup> helper T (Th17) cells in both spleen and cervical lymph node (cLN) cells. Additionally, the ratios of regulatory T cell (Treg)\/Tfh cells and Treg\/Th17 cells are substantially increased in mice treated with LBP.L in both spleen and cLNs. LBP also inhibits Th17 and Tfh cells and markedly increases the Treg\/Tfh ratio in human peripheral blood mononuclear cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LBP.L inhibits the progression of pSS in mice, associated with modulation of T cell differentiation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202001118","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T04:15:05Z","timestamp":1617768905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<i>Lycium barbarum<\/i> Polysaccharide Ameliorates Sj\u00f6gren's Syndrome in a Murine Model"],"prefix":"10.1002","volume":"65","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-4190","authenticated-orcid":false,"given":"Jia","family":"Xiao","sequence":"additional","affiliation":[{"name":"Clinical Research Institute and Department of Interventional Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Beijing Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebo","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok\u2010Fai","family":"So","sequence":"additional","affiliation":[{"name":"GMH Institute of Central Nervous System Regeneration Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_10_1_1","first-page":"3","volume":"37","author":"Cafaro G.","year":"2019","journal-title":"Clin. 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