{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:06:46Z","timestamp":1779163606548,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Turmeric has a broad spectrum of biological properties; however, the sleep\u2010promoting effects of turmeric have not yet been reported. Thus, this study aims to investigate the effect of turmeric on sleep and the molecular mechanism underlying this effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Pentobarbital\u2010induce sleep test and sleep\u2010wake profile assessment using recorded electroencephalography are used to evaluate the hypnotic effects of the turmeric extract (TE) compared to diazepam on sleep in mice. Additionally, the molecular mechanism of TE's sleep effect is investigated using ex vivo electrophysiological recordings from brain slices in histamine H<jats:sub>1<\/jats:sub> receptor (H<jats:sub>1<\/jats:sub>R) knockout mice. Oral administration of TE and diazepam significantly reduce sleep latency and increase non\u2010rapid eye movement sleep (NREMS) duration without delta activity in mice. Like doxepin, TE inhibits the H<jats:sub>1<\/jats:sub>R agonist (2\u2010pyridylethylamine dihydrochloride)\u2010induced increase in action potentials in the hypothalamic neurons. In animal tests using neurotransmitter agonists or antagonists, TE effect mimick H<jats:sub>1<\/jats:sub>R antagonistic effect of doxepin. Additionally, both reduce sleep latency and increase NREMS in wild\u2010type mice, although these effects are not observed in H<jats:sub>1<\/jats:sub>R knockout mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TE has a sleep\u2010promoting effect owing to reduction in sleep latency and enhancement of NREMS via H<jats:sub>1<\/jats:sub>R blockade; therefore, it could be useful in insomnia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100100","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T15:49:02Z","timestamp":1621352942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Novel Potent Sleep\u2010Promoting Effect of Turmeric: Turmeric Increases Non\u2010Rapid Eye Movement Sleep in Mice Via Histamine H<sub>1<\/sub>Receptor Blockade"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-8837","authenticated-orcid":false,"given":"Min Young","family":"Um","sequence":"first","affiliation":[{"name":"Research Division of Food Functionality Korea Food Research Institute  Wanju 55364 Republic of Korea"},{"name":"Division of Food Biotechnology University of Science &amp; Technology  Daejeon 34113 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality Korea Food Research Institute  Wanju 55364 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-5212","authenticated-orcid":false,"given":"Jaekwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality Korea Food Research Institute  Wanju 55364 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality Korea Food Research Institute  Wanju 55364 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-5832","authenticated-orcid":false,"given":"Suengmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology\/Institute of Food Science Pukyong National University  Busan 48513 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.072"},{"key":"e_1_2_9_2_1","first-page":"1354","volume":"6","author":"Verma R. K.","year":"2018","journal-title":"Int. J. Chem. Stud."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.01.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.04.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7656919"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-3-71"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.04.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13621"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9027206"},{"key":"e_1_2_9_11_1","first-page":"141","volume":"14","author":"Jurenka J. S.","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.03.006"},{"key":"e_1_2_9_13_1","first-page":"273","volume":"36","author":"Soni K. B.","year":"1992","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2005.08.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2008.11.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.07.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.29.1.5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700316"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.116.105080"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172508"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02010.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.2.259"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12336"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09142FP"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0580-17.2017"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.12.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.06.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-04-01523.1996"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v03n0303"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600451103"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13316"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.07.003"},{"key":"e_1_2_9_34_1","first-page":"142","volume":"118","author":"Yuliani S.","year":"2017","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.026"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3445-1"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.202100100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:58:11Z","timestamp":1693360691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202100100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":37,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/mnfr.202100100"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202100100","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]},"assertion":[{"value":"2021-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100100"}}