{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:24:10Z","timestamp":1778948650248,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002327"],"award-info":[{"award-number":["32002327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p><jats:italic>Salmonella<\/jats:italic> is the main food\u2010borne pathogen, which can infect intestinal epithelial cells and causes colitis. Genistein has a variety of biological activities that alleviates colitis induced by sodium dextran sulfate in a variety of ways, but its protective effects on colitis caused by pathogenic bacteria are still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This study explores the protective effect of genistein in reducing colitis caused by <jats:italic>Salmonella<\/jats:italic> infection. <jats:italic>Salmonella<\/jats:italic> causes colon inflammation through activating cyclooxygenase\u20102\/prostaglandin E2, and genistein inhibits colitis caused by <jats:italic>Salmonella<\/jats:italic> typhimurium infection. <jats:italic>Salmonella<\/jats:italic> infection increases colonic mucosal damage, proliferating cells, and goblet cell loss, while the administration of genistein solves these pathological changes. In addition, it is further proved that <jats:italic>Salmonella<\/jats:italic> causes severe colitis related to goblet cell loss and activates the host crypt stem cells to repair the damaged epithelium. <jats:italic>Salmonella<\/jats:italic> infection inhibites the host mammalian target of rapamycin, activates light chain 3 II pathways to induce autophagy to eliminate pathogenic bacteria. Genistein increases <jats:italic>Lactobacillus<\/jats:italic> in feces and reduces <jats:italic>Salmonella<\/jats:italic> colonization to inhibit colitis induces by <jats:italic>Salmonella<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates genistein alleviated colitis and inhibites the goblet cell loss causes by <jats:italic>Salmonella<\/jats:italic> infection through regulating the gut bacteria and intestinal stem cell development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100209","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T13:26:07Z","timestamp":1624109167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genistein Inhibits Colonic Goblet Cell Loss and Colorectal Inflammation Induced by <i>Salmonella<\/i> Typhimurium Infection"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-8990","authenticated-orcid":false,"given":"Yang","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"},{"name":"College of Veterinary Medicine China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hammed","family":"Ayansola","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihang","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyong","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Lei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Lai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hori","family":"Masatoshi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology Graduate School of Agricultural and Life Sciences The University of Tokyo  Bunkyo\u2010ku Tokyo 113\u20148657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingkun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition Department of Animal Nutrition &amp; Feed Science College of Animal Science &amp; Technology China Agricultural University  Haidian District Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00078"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12628"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.09.073"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0021-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0036-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11811-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx029"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7110574"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900274"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18219"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.08.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800313"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01951K"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600462"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199631"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2017.12.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201021666200711152726"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01718F"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700572"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12563"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800552"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.08.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/310183"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00378"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.811737"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.06.133"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-020-00823-8"},{"key":"e_1_2_9_36_1","volume":"51","author":"Cao Z.","year":"2019","journal-title":"Acta Biochem. Biophys. Sin"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.072"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.034"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.05.006"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14655-9"},{"key":"e_1_2_9_41_1","first-page":"735","volume":"20","author":"Dong H.","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27411"},{"key":"e_1_2_9_43_1","author":"Liu W.","year":"2020","journal-title":"Cell. Microbiol."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.03.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0084-4"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.10.009"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0199-y"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900564"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.01.013"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061630"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2013.86"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26083-3"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.202100209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:22:27Z","timestamp":1693290147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202100209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":53,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/mnfr.202100209"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202100209","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"2021-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100209"}}