{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:46:39Z","timestamp":1785545199753,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K11624"],"award-info":[{"award-number":["JP20K11624"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["P18K19746"],"award-info":[{"award-number":["P18K19746"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Hyperoxaluria is a major cause of kidney stone disease. Around half of the oxalate in mammals is supplied from the diet and the other half is endogenously synthesized from glyoxylate. Reduction of hepatic glycolate oxidase (GO) activity is one approach to reduce endogenous production of oxalate. However, there are currently few effective dietary approaches to reduce hepatic GO activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In the present study, it is investigated whether restriction of dietary vitamin B2 (VB2) can reduce hepatic GO activity and oxalate excretion in mice with hyperoxaluria induce by hydroxyproline (Hyp) or obesity. It is found that VB2 restriction significantly reduces hepatic GO activity in both the Hyp\u2010 and obesity\u2010induced model of hyperoxaluria in mice. However, VB2 restriction reduces urinary oxalate excretion only in the Hyp\u2010treated mice and not the obese mice. This difference could be due to the contribution of endogenous oxalate production that manifests as increased hepatic GO activity in Hyp\u2010treated mice but not obese mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Together these results suggest that VB2 restriction could be a new dietary approach to improve hyperoxaluria when endogenous production of oxalate is increased.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100226","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T19:26:29Z","timestamp":1623353189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Vitamin B2\u2010Deficient Diet on Hydroxyproline\u2010 or Obesity\u2010Induced Hyperoxaluria in Mice"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-7676","authenticated-orcid":false,"given":"Takashi","family":"Uebanso","sequence":"first","affiliation":[{"name":"Department of Preventive Environment and Nutrition Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20138503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Preventive Environment and Nutrition Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20138503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Shimohata","sequence":"additional","affiliation":[{"name":"Department of Preventive Environment and Nutrition Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20138503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Mawatari","sequence":"additional","affiliation":[{"name":"Department of Preventive Environment and Nutrition Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20138503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Preventive Environment and Nutrition Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20138503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3068365"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590600589898"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2008-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.09.034"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.03.052"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.320"},{"key":"e_1_2_9_9_1","unstructured":"J.Talati H.\u2010G.Tiselius D. 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