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Previous studies reveal a relationship between dietary omega\u20103 polyunsaturated fatty acid (n\u20103 PUFA) content, brain development, and the prevalence of neurodevelopmental disorders and inflammation. However, it is unclear about the effect of n\u20103 PUFA\u2010deficiency in early life on the development of Parkinson's disease (PD) in old age, as well as the neuroprotective effect of DHA\u2010 and EPA\u2010enriched phospholipids (DHA\/EPA\u2010PLs) supplemented in old age in long\u2010term n\u20103 PUFA\u2010deficient mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The PD mice induced by 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010 tetrahydropyridine (MPTP) in n\u20103 PUFA\u2010adequate (N) and \u2010deficient (DEF) group are supplemented with a DHA\/EPA\u2010PLs diet for 2 weeks (N+DPL, DEF+DPL). DHA\/EPA\u2010PLs supplementation significantly protects against MPTP\u2010induced impairments. The DEF+DPL group shows poorer motor performance, the loss of dopaminergic neurons, mitochondrial dysfunction, and neurodevelopment delay than the N+DPL group, and still did not recover to the Control level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dietary n\u20103 PUFA\u2010deficiency in early life exhibits more aggravated MPTP\u2010induced neurotoxicity in old age, than DHA\/EPA\u2010PLs supplementation recovers brain DHA levels and exerts neuroprotective effects in old age in long\u2010term n\u20103 PUFA\u2010deficient mice, which might provide a potential dietary guidance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100339","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T11:51:15Z","timestamp":1628682675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["N\u20103 PUFA\u2010Deficiency in Early Life Exhibits Aggravated MPTP\u2010Induced 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