{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:07:14Z","timestamp":1793642834393,"version":"4.5.1"},"reference-count":56,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Dietary polyphenols can alter the gut microbiota (GM) and promote the production of bioactive metabolites. Several indoles result of GM metabolism of dietary tryptophan have been associated with intestinal barrier integrity. Our aim is to study the changes in GM\u2010derived indoles during a polyphenol\u2010rich (PR) diet intervention in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Randomized, controlled, crossover trial in adults \u2265 60\u00a0years living in a residential care facility during an 8\u2010week PR versus control diet (\n                      <jats:italic>n<\/jats:italic>\n                      = 51). Seven GM\u2010tryptophan metabolites are measured in serum, and metataxonomic analysis of GM is performed on fecal samples. Exploratory subgroup analyses are performed based on renal function (RF). The PR\u2010diet significantly increases serum indole 3\u2010propionic acid (IPA) in subjects with normal RF, but not in subjects with impaired RF. Other GM\u2010tryptophan metabolites are not affected. Comparison of baseline GM composition shows shifts in Bacteroidales order members as well as higher abundance of Clostridiales in participants with normal RF. During the trial, variations of IPA are associated with changes in C\u2010reactive protein (\u03b2 = 0.32,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.010) and GM, particularly with the Clostridiales (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.35,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and Enterobacteriales (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.15,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) orders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A PR diet increases the serum concentration of IPA in older adults with normal RF. Our findings may be important when defining appropriate dietary interventions for older adults.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registration number<\/jats:bold>\n                      : ISRCTN10214981 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN10214981\">https:\/\/doi.org\/10.1186\/ISRCTN10214981<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202100349","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T07:02:01Z","timestamp":1647932521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A Polyphenol\u2010Rich Diet Increases the Gut Microbiota Metabolite Indole 3\u2010Propionic Acid in Older Adults with Preserved Kidney 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