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This study found that LC alleviates the growth retardation of mice and repairs the damaged jejunal structure and barrier functions under DON exposure. LC rescues the intestinal stem cells (ISCs), increases the growth advantage in enteroids derived from jejunal crypts of mice in each group ex vivo, improves the proliferation and apoptosis of intestinal cells, and promotes ISC differentiation into absorptive cells, goblet cells, and Paneth cells. Furthermore, LC activates Nrf2 signaling by binding to Keap1 to reverse the striking DON\u2010induced increase in ROS levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study findings unveil that LC potentiates the antioxidant capacity of ISCs by regulating the Keap1\/Nrf2 signaling pathway, which contributes to the intestinal epithelial regeneration response to DON insult.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100406","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:40:30Z","timestamp":1625319630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["<scp>l<\/scp>\u2010Carnosine Protects Against Deoxynivalenol\u2010Induced Oxidative Stress in Intestinal Stem Cells by Regulating the Keap1\/Nrf2 Signaling 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