{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:09Z","timestamp":1790774409843,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015871","name":"Groupe Lipides et Nutrition","doi-asserted-by":"publisher","award":["Award 2017"],"award-info":[{"award-number":["Award 2017"]}],"id":[{"id":"10.13039\/100015871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The effect of vitamin A deficiency on vitamin A and lipid postprandial metabolism in young rats is addressed, considering the effect of sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Sprague\u2010Dawley rats are fed either 400 UI.kg<jats:sup>\u22121<\/jats:sup> vitamin A diet (vitamin A\u2010deficient (VAD) diet) or 2300 UI.kg<jats:sup>\u22121<\/jats:sup> vitamin A (control diet), before being mated. Mothers receive the same VAD or control diet during gestation and lactation. Offspring receive the same diet than mothers until 8 weeks of age. VAD diet\u2010fed female and male offspring display a severe vitamin A deficiency with no body weight or glucose tolerance defects. Fasting plasma triglyceride concentrations are decreased in VAD diet\u2010fed animals compared to controls (<jats:italic>p<\/jats:italic> &lt; 0.05). Retinyl ester postprandial responses after vitamin A gavage, expressed as area under the curves, are not different in VAD diet\u2010fed and control animals, although retinyl ester postprandial peak is significantly delayed (<jats:italic>p<\/jats:italic> &lt; 0.05) in VAD diet\u2010fed rats. Lipids also accumulate in the distal part of the intestine after gavage and [1\u2010<jats:sup>13<\/jats:sup>C]\u2010oleate postprandial response is decreased in VAD diet\u2010fed males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin A deficiency modulates both vitamin A absorption rate and lipid postprandial metabolism, which can partly explain the altered fasting lipid status observed in VAD diet\u2010fed offspring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100451","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T17:56:11Z","timestamp":1631469371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin A Deficiency during the Perinatal Period and First Weeks of Life Modifies Vitamin A and Lipid Postprandial Metabolism in Both Female and Male Young Rats"],"prefix":"10.1002","volume":"65","author":[{"given":"Tiffany","family":"Antoine","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-3238","authenticated-orcid":false,"given":"Patrick","family":"Borel","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Govers","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-8899","authenticated-orcid":false,"given":"Laure","family":"Meiller","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Nutrition Humaine Rh\u00f4ne\u2010Alpes INSERM INRAE Universit\u00e9 Claude Bernard Lyon 1 Hospices Civils de Lyon Centre Hospitalier Lyon Sud Univ\u2010Lyon  Pierre B\u00e9nite F\u201069310 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Guichard","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Halimi","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Sauvinet","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Nutrition Humaine Rh\u00f4ne\u2010Alpes INSERM INRAE Universit\u00e9 Claude Bernard Lyon 1 Hospices Civils de Lyon Centre Hospitalier Lyon Sud Univ\u2010Lyon  Pierre B\u00e9nite F\u201069310 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Grino","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-1992","authenticated-orcid":false,"given":"Emmanuelle","family":"Reboul","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 INRAE INSERM C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093563"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1994.tb01382.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1160362"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030681"},{"key":"e_1_2_9_5_1","volume-title":"Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995\u20132005: WHO Global Database on Vitamin A Deficiency","author":"WHO","year":"2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2000.tb01831.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00039-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344398"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.06.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1316"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.197"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.5067"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_9_15_1","first-page":"624","volume":"4","author":"Sengupta P.","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60607-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400339"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1532-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.149039"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.1.106"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/105.10.1299"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28821"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.616763"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.65"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120001066"},{"key":"e_1_2_9_26_1","first-page":"233","volume":"50","author":"Wiss O.","year":"1980","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507182659"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300116-JLR200"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-150995"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.444240"},{"key":"e_1_2_9_31_1","first-page":"126","volume":"3","author":"Li Y.","year":"2014","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.10.2264"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/40.6.1281"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.5.911"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz199"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.01.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.02.003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700345-JLR200"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.11.002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.10.011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0250-7"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.202100451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:09:29Z","timestamp":1693210169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202100451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":41,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/mnfr.202100451"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202100451","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,27]]},"assertion":[{"value":"2021-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100451"}}