{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:28:42Z","timestamp":1779312522678,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102012\u2010StG310898"],"award-info":[{"award-number":["ERC\u20102012\u2010StG310898"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Furfuryl alcohol is a heat\u2010induced food contaminant, classified as possibly carcinogenic to humans. The proximal carcinogen 2\u2010sulfoxymethylfuran leads to adduct formation in DNA and proteins (e.g., <jats:italic>N<\/jats:italic>\u2010((furan\u20102\u2010yl)methyl)\u2010Val (FFA\u2010Val) in hemoglobin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This study analyzed human erythrocyte samples from two studies for the presence of FFA\u2010Val: the <jats:italic>Risks and Benefits of a Vegan Diet<\/jats:italic> study (RBVD; 72 adults) and the ENVIRonmental influence <jats:italic>ON<\/jats:italic> early AGEing birth cohort study (ENVIR<jats:italic>ON<\/jats:italic>AGE; 100 mother\u2010newborn pairs). In the RBVD study, FFA\u2010Val levels are lower in vegans compared to omnivores (median 13.0 vs 15.8\u00a0pmol g<jats:sup>\u22121<\/jats:sup> hemoglobin, <jats:italic>p<\/jats:italic> = 0.008), and lower in non\u2010smokers compared to smokers (median 14.1 vs 17.0\u00a0pmol g<jats:sup>\u22121<\/jats:sup> hemoglobin, <jats:italic>p<\/jats:italic> = 0.003). In the birth cohort, FFA\u2010Val levels are distinctly higher in maternal compared to newborn samples (median 15.2 vs 2.2\u00a0pmol g<jats:sup>\u22121<\/jats:sup> hemoglobin, <jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FFA\u2010Val, hitherto detected only in blood samples of mice, is quantifiable in all human samples, indicating a general exposure to furfuryl alcohol. The low adduct levels in blood samples from newborn children suggested that the placenta is a barrier to furfuryl alcohol. Dietary habits and tobacco smoking are two main influencing factors on the formation of FFA\u2010Val, which may be of use as a biomarker of exposure to furfuryl alcohol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100584","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T18:33:36Z","timestamp":1634495616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of a Hemoglobin Adduct of\u00a0the Food Contaminant\u00a0Furfuryl Alcohol in Humans: Levels of\u00a0<i>N<\/i>\u2010((Furan\u20102\u2010yl)methyl)\u2010valine in Two Epidemiological\u00a0Studies"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-2352","authenticated-orcid":false,"given":"Bernhard H.","family":"Monien","sequence":"first","affiliation":[{"name":"Department of Food Safety German Federal Institute for Risk Assessment (BfR)  Max\u2010Dohrn\u2010Strasse 8\u201310 Berlin 10589 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Bergau","sequence":"additional","affiliation":[{"name":"Department of Food Safety German Federal Institute for Risk Assessment (BfR)  Max\u2010Dohrn\u2010Strasse 8\u201310 Berlin 10589 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke G. F.","family":"Hogervorst","sequence":"additional","affiliation":[{"name":"Centre for Environmental Sciences Hasselt University  Agoralaan gebouw D Diepenbeek 3590 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim S.","family":"Nawrot","sequence":"additional","affiliation":[{"name":"Centre for Environmental Sciences Hasselt University  Agoralaan gebouw D Diepenbeek 3590 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Trefflich","sequence":"additional","affiliation":[{"name":"Department of Food Safety German Federal Institute for Risk Assessment (BfR)  Max\u2010Dohrn\u2010Strasse 8\u201310 Berlin 10589 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Weikert","sequence":"additional","affiliation":[{"name":"Department of Food Safety German Federal Institute for Risk Assessment (BfR)  Max\u2010Dohrn\u2010Strasse 8\u201310 Berlin 10589 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-9909","authenticated-orcid":false,"given":"Klaus","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Food Safety German Federal Institute for Risk Assessment (BfR)  Max\u2010Dohrn\u2010Strasse 8\u201310 Berlin 10589 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"43","volume-title":"in Chemical Food Safety and Health","author":"Murkovic M."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.05.055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30505-3"},{"key":"e_1_2_9_4_1","author":"National Toxicology Program","year":"1999","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"key":"e_1_2_9_5_1","first-page":"1","volume":"215","author":"European Food Safety Authority","year":"2005","journal-title":"EFSA J."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(81)90133-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(89)90160-9"},{"key":"e_1_2_9_8_1","first-page":"353","volume":"13","author":"Shinohara K.","year":"1986","journal-title":"Dev. Food Sci."},{"key":"e_1_2_9_9_1","first-page":"328","volume-title":"in Acrylamide and Other Health Hazardous Compounds in Heat\u2010treated Foods","author":"Glatt H. R.","year":"2006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr126"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu152"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac503803m"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics5010009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf970559r"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/41.6.305"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990140w"},{"key":"e_1_2_9_17_1","author":"Liguori L.","year":"2017","journal-title":"J. Food Qual."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.12.091"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018-15714"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2005.04.003"},{"key":"e_1_2_9_21_1","first-page":"251","volume":"12","author":"Sakuma H.","year":"1984","journal-title":"Contrib. Tob. Res."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.10.012"},{"key":"e_1_2_9_23_1","author":"Rydberg P.","year":"2009","journal-title":"Int. J. Anal. Chem."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.06.008"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2005-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx033"},{"key":"e_1_2_9_27_1","first-page":"575","volume":"117","author":"Weikert C.","year":"2020","journal-title":"Dtsch. \u00c4rztebl. Int."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2373-y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi069"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf703750t"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics7010007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx200284u"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2020.06.013"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80410-4"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.05.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf703749h"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.058"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.suppl_1.S59"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.202100584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202100584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:23:36Z","timestamp":1693207416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202100584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":38,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/mnfr.202100584"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202100584","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]},"assertion":[{"value":"2021-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100584"}}