{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:22:59Z","timestamp":1789064579833,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the antidiabetic effect of lariciresinol (LSR) in C2C12 myotubes and streptozotocin (STZ)\u2010induced diabetic mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      To investigate antidiabetic potential of LSR, \u03b1\u2010glucosidase inhibitory assay, molecular docking, glucose uptake assay, western blot assay on antidiabetic biomarkers are performed. STZ\u2010induced diabetic model is used for in vivo study by calculating oral glucose tolerance test, histochemical examination, and glycogen assay. LSR inhibits \u03b1\u2010glucosidase activity with an IC\n                      <jats:sub>50<\/jats:sub>\n                      value of 6.97\u00a0\u00b1 0.37\u00a0\u00b5M and acts as a competitive inhibitor with an inhibitory constant (Ki) value of 0.046\u00a0\u00b5M. In C2C12 cells, LSR activates insulin signaling leading to glucose transporter 4 (GLUT4) translocation and augmented glucose uptake. Furthermore, in Streptozotocin (STZ)\u2010treated diabetic mice, 3 weeks of oral LSR administration (10\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) considerably decrease blood glucose levels, while increasing insulin levels in an oral glucose tolerance test, improve pancreatic islet size, increase GLUT4 expression, and significantly enhance insulin signaling in skeletal muscle. LSR treatment also activates glycogen synthase kinase 3\u03b2 (GSK\u20103\u03b2) resulting in improved glycogen content.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate a potential usefulness for oral LSR in the management and prevention of diabetes by enhancing glucose homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202100751","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T08:09:10Z","timestamp":1651392550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lariciresinol Displays Anti\u2010Diabetic Activity through Inhibition of \u03b1\u2010Glucosidase and Activation and Enhancement of Insulin Signaling"],"prefix":"10.1002","volume":"66","author":[{"given":"Md Badrul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"},{"name":"Food and Bio\u2010Industry Research Institute Inner Beauty\/Anti\u2010Aging Center Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Sic","family":"Ra","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Rim","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-7315","authenticated-orcid":false,"given":"Sang\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Graduate School Kyungpook National University Daegu 41566 Republic of Korea"},{"name":"Food and Bio\u2010Industry Research Institute Inner Beauty\/Anti\u2010Aging Center Kyungpook National University Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5796102","volume":"2018","author":"Alam M. 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