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Since antioxidants can slow down AMD progression, the intake of foods and drinks rich in antioxidant compounds may reduce retinal damage. <jats:italic>Ilex paraguariensis<\/jats:italic> (yerba mate, YM) extracts reduce oxidative damage of RPE cells in vitro as shown in previous study. Here, the effects of YM drinking on RPE and photoreceptor survival after oxidative damage with sodium iodate (NaIO3; SI) in a murine AMD model are described. Funduscopy and histology show that YM treatment prevents RPE and photoreceptor damage. YM also increases the expression of NRF2, the master antioxidant gene, and its effectors HO\u20101 and SOD2. In mice receiving YM and SI, the antioxidant response is larger than in mice receiving YM or SI alone. The YM drink also increases expression of RPE65, a gene that is involved in the functionality and survival of photoreceptors and RPE cells. The results suggest YM can play an important role in the prevention of retinal damage associated with oxidative stress, such as AMD.<\/jats:p>","DOI":"10.1002\/mnfr.202100807","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:19:31Z","timestamp":1647163171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Ilex paraguariensis<\/i> Extracts Prevent Oxidative Damage in a Mouse Model of Age\u2010Related Macular Degeneration"],"prefix":"10.1002","volume":"66","author":[{"given":"Pablo S.","family":"Tate","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Medicina Traslacional (IIMT, Universidad Austral\u2010CONICET), Facultad de Ciencias Biom\u00e9dicas Universidad Austral  Pilar Buenos Aires B1629AHJ Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa D.","family":"Marquioni\u2010Ramella","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Medicina Traslacional (IIMT, Universidad Austral\u2010CONICET), Facultad de Ciencias Biom\u00e9dicas Universidad Austral  Pilar Buenos Aires B1629AHJ Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Cerchiaro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Medicina Traslacional (IIMT, Universidad Austral\u2010CONICET), Facultad de Ciencias Biom\u00e9dicas Universidad Austral  Pilar Buenos Aires B1629AHJ Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-3301","authenticated-orcid":false,"given":"Angela M.","family":"Suburo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Medicina Traslacional (IIMT, Universidad Austral\u2010CONICET), Facultad de Ciencias Biom\u00e9dicas Universidad Austral  Pilar Buenos Aires B1629AHJ Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.101013"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR120000850"},{"key":"e_1_2_7_3_1","first-page":"3928","volume-title":"Ryan's Retina","author":"Wenick A. 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